Linköping University Medical Dissertations No. 1567
Kappa Står Ändras till
s. 21, rad 6 dialysate perfusate
s. 30, underrubriken Deep Brain Stimulation Deep Brain Stimulation and stereotactic microdialysis
s. 43, Figure 15 patients 2-5 patients 2, 3 and 5
s. 44, Figure 16 left Gpi right Gpi
s. 46, rad 5 …right structures in striatum… …right Gpi structures and left stimulation seemed to have a more pronounced effect on left Gpi structures while all STN stimulation seemed to have effect on right putamen. s. 51, rad 38 …left-side structures… …left-side Gpi structures during left-side
stimulation, an increase of DA in the right-side Gpi structures during right-side stimulation and an increase of DA in right putamen during all STN stimulation indicating a direct action on SNc as we also found evidence for in paper III. s. 51, rad 40 This supports This could also support
Delarbete III
s. 150, Microdialysis, rad 17 3 h 6 h
s. 150, Microdialysis, rad 17 …continued for another 3 h. …continued further on.
s. 152, Figure 2 patients 2-5 patients 2, 3 and 5
s. 152, Figure 3 left globus pallidum right globus pallidum
s. 153, Patient 4, rad 6, efter mening 3 Due to technical failure in the beginning of the infusion period and prolonging of the second infusion period this patient was given levodopa infusion for 1 + 7 h (instead of 3 + 6 h). This patient was excluded from the dopamine results in Figure 2. The mean GABA curves with and without patient 4 had similar appearance and therefore patient 4 was included in the GABA results in Figure 3.
s. 154, kolumn 2, rad 1 left Gpi right Gpi
s. 154, kolumn 2, rad 2 right Gpi left Gpi
Levodopa pharmacokinetics -from stomach to brain:
A study on patients with Parkinson’s disease
by Maria Nord
0 500 1000 1500 2000 2500 3000 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Right putamen Right Gpi Left Gpi Le vo do pa co nc. ,% co m pa re d t o fra ct io n 1 Fraction, No. 0 100 200 300 400 500 600 700 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Right putamen Right Gpi Left Gpi Do pa m in e co nc. , % co m pa re d to fra ct io n 1 Fraction, No. 0 200 400 600 800 1000 1200 1400 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 Right putamen Right Gpi Left Gpi Fraction, No. Le vo do pa co nc. ,% co m pa re d t o fra ct io n 1 0 100 200 300 400 500 600 700 800 900 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 Right putamen Right Gpi Left Gpi Fraction, No. Do pa m in e co nc. , % co m pa re d to fra ct io n 1
Delarbete IV, publicerad version finns tillgänglig på http://www.scirp.org/journal/apd/
Står Ändras till
Abstract, rad 15 Left STN DBS… Left STN DBS seemed to increase DA levels in left Gpi and right STN DBS seemed to increase DA levels in right Gpi while all STN stimulation seemed to increase the DA levels in right putamen.
s. 3, rad 24 …CNS microdialysis samples… …microdialysis samples from brain... s .3, tillägg efter sista meningen The HPLC analyses of the dialysates from
central nervous system (CNS) were purchased from Pronexus Analytical AB, Stockholm, Sweden.
s. 4, Statistics, rad 2 differences changes
s. 4, Statistics, rad 4 …left Gpi. The values… …left Gpi and these values…
s. 6, Figure 3 ändrade y-axlar, vg se separat bild
s. 6, text till Figure 3 differences changes
s. 7, rad 7 284 % 294 %
s. 7, rad 13 During left STN DBS… During left STN DBS (fraction 9 - 11) the DA level increased in left Gpi and in right putamen while it decreased in right Gpi.
s. 7, rad 30 fraction 7 fraction 34
s. 7, rad 32 The differences between… The differences between Cmax and Cmin during
the period with continuous levodopa IV (fraction 32 - 38) were 68%, 214% and 220% for levodopa and 317%, 54% and 307% for DA in right putamen, right Gpi and left Gpi respectively.
s. 8, rad 33 Thus it seems It seems
s. 9, rad 43 In the actual report… In the actual report we could confirm these
observations and we could also see an increase of DA in the left-sided Gpi structures during left-sided stimulation and an increase in the right-sided Gpi structures during right-sided stimulation also indicating a direct action on SNc.
