A Podocyte view on RhoGTPases and actin cytoskeleton regulation

We could show that Smad7 is required for TGF-β-induced activation of the TGF-β activated kinase 1 (TAK1)- mitogen-activated protein kinase kinase 3 (MKK3)-p38 MAPK pathway,

The signaling can be dependent or independent of the protease activated receptors (PAR) PAR2 and PAR1, the TF cytoplasmic domain, by activation of integrins and

The researchers suggest, from the results of the two studies, that the emotion regulation strategy reappraisal may influence risk-taking attitudes, in the way that when

In paper II we therefore set out in investigating the role of geranylgeranylation of RhoGTPases in podocytes and the consequential effects on RhoGTPase activity, foot

Eukaryotic cells experiencing protein misfolding and aggregation can organize the damaged proteins into specific spatial quality control deposits; aggresomes, IPOD and JUNQ deposits

Earlier studies established a role for the histone deacetylase Sir2 and the actin cytoskeleton in the asymmetrical inheritance of damaged proteins by the mother cell, as cells

The specific aims were to investigate epigenetic mechanisms regulating tissue-type plasminogen activator (t-PA) gene expression in the human brain (Paper I); to identify

Thus, in this thesis, we also investigated whether INSL5 and the gut microbiota directly contributes to the metabolic improvements following the bariatric procedure called