Type III Secretion in Yersinia: Injectisome or Not?
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Type III secretion system, virulence, translocation, Yersinia pseudotuberculosis, LcrV, YopN, effector targeting, phagocytosis inhibition, YopH, in vivo infection.
Correct autoproteolysis of YscU is needed to place negative regulation on Yop secretion and T3SS induction, and either target cell contact or calcium depletion,
These include (i) Ysc (Yersinia secretion) proteins required for the secretion process, (ii) secreted effector proteins called Yops (Yersinia outer protein), (iii) proteins
One class of secreted substrates, translocators, are required for the intracellular targeting of the second class, the virulence effectors, into host target cells. T3SSs are