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Molecular Biotechnology Programme Uppsala University School of Engineering

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Molecular Biotechnology Programme

Uppsala University School of Engineering

UPTEC X 06 035 Date of issue 2006-08

Author

Pia Damm

Title (English)

Insulin-like growth factor II and its mimetic peptides

Title (Swedish)

Abstract

The insulin-like growth factor I and II (IGF-I and -II) are structurally similar polypeptides with neurotrophic effects, particularly important in the development of the nervous system.

The actions of both factors are mainly mediated through the IGF-I receptor (IGF-IR).

However, the knowledge of the IGF-II IGF-IR interaction is very limited. In this master’s thesis IGF-II was characterized by studying the ability of IGF-II derived peptides to bind to IGF-IR and differentiate neurons. Four peptides were found to exhibit neuritogenic effect and two of those shown to bind to the IGF-IR, but also to the IGF-II receptor (IGF-IIR) and the insulin receptor (IR). Thus, the peptides contain IGF-II sites responsible for binding to and activation of IGF-IR, as well as binding to IGF-IIR and IR. Impairment in IGF-I and IGF-II signaling has previously been observed in several neurodegenerative disorders and in relation to this, the IGF-II mimetic peptides may serve as a therapeutic rescue.

Keywords

IGF-II derived peptides, neuritogenesis, binding sites, IGF-I receptor activation, neurodegenerative disorders

Supervisors

Elisabeth Bock and Vladimir Berezin

Protein Laboratory, Institute of Molecular Pathology, University of Copenhagen

Scientific reviewer

Dan Lindholm

Institute of Neuroscience, Uppsala University

Project name Sponsors

Language

English

Security

ISSN 1401-2138 Classification

Supplementary bibliographical information

Pages

65

Biology Education Centre Biomedical Center Husargatan 3 Uppsala

Box 592 S-75124 Uppsala Tel +46 (0)18 4710000 Fax +46 (0)18 555217

References

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