Influence of CYP3A enzymes and ABC transporters on the activity of tyrosine kinase inhibitors in

Model-based simulations were performed to investigate four different scenarios: (I) the predicted value of high-dose pulsatile schedules to improve clinical outcomes as compared

The specific aims of this thesis were: (i) to investigate the possible influence of serotonin-related genetic variation on the neural correlates of anxiety, and on mood-

Bhargava R, Gerald WL, Li AR, Pan Q, Lal P, Ladanyi M, Chen B: EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein

In this method of cancer treatment, the molecules have the ability to bind to the receptor and block the signal and therefore inhibit the dangerous cell growth. What the

And Syk expression in a human cervical tumor cell line was at an undetectable level; Syk (L) was the only type in the selected blood cell line, while both types of Syk

Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up

The primary aim of the present thesis was to investigate the influence of CYP3A metabolic activity and cellular transport mediated by genetic variants of ABCB1 and ABCG2

The results from calculations of solvation free energies with structures obtained by homology protein modeling, namely the kinase domain in active state and in inactive state,