Mast cells in Hodgkin lymphoma: or 'What's a nice cell like you doing in a tumour like this?'

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(1)Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1380. Mast cells in Hodgkin lymphoma or 'What's a nice cell like you doing in a tumour like this?' BY. MARIE FISCHER. ACTA UNIVERSITATIS UPSALIENSIS UPPSALA 2004.

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(159) “Never measure the height of a mountain until you have reached the top” Dag Hammarskjöld.

(160) Front page: A tryptase positive mast cell next to a Hodgkin and Reed-Sternberg cell All figures except figure 7 drawn by Mia Enarsson Ɔ. =.

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(165) Abbreviations. â= îì= `ì= `ò= à= ëàPM= àPMi= `qj`= ùPò= ùì= ùò= b_s= cÅİof= ei= eop= fck= fÖb= fi= iaei= ioèi= j`q= j`q`= jèi= jj`= kcț_= kdc= kimei= kpei= mô= p`c= qe= qio= qkc= =. ^íçéáÅ=ÇÉêã~íáíáë= ^å~éä~ëíáÅ=ä~êÖÉ=ÅÉää=äóãéÜçã~= ``JÅÜÉãçâáåÉ=äáÖ~åÇ= ``JÅÜÉãçâáåÉ=êÉÅÉéíçê= `äìëíÉê=çÑ=ÇáÑÑÉêÉåíá~íáçå= pçäìÄäÉ=àPM= àPM=äáÖ~åÇ= `çååÉÅíáîÉ=íáëëìÉ=ã~ëí=ÅÉää== ùPòJÅÜÉãçâáåÉ=êÉÅÉéíçê= ù`JÅÜÉãçâáåÉ=äáÖ~åÇ= ù`JÅÜÉãçâáåÉ=êÉÅÉéíçê= béëíÉáåJ_~êê=îáêìë= eáÖÜ=~ÑÑáåáíó=êÉÅÉéíçê=Ñçê=fÖb= eçÇÖâáå=äóãéÜçã~= eçÇÖâáå=~åÇ=oÉÉÇJpíÉêåÄÉêÖ== fåíÉêÑÉêçå= fããìåçÖäçÄìäáå=áëçíóéÉ=b= fåíÉêäÉìâáå= ióãéÜçÅóíÉJÇÉéäÉíÉÇ=ei= ióãéÜçÅóíÉJêáÅÜ=Åä~ëëáÅ~ä=ei= qêóéí~ëÉ=éçëáíáîÉ=ã~ëí=ÅÉääë= qêóéí~ëÉ=~åÇ=ÅÜóã~ëÉ=éçëáíáîÉ=ã~ëí=ÅÉääë= jáñÉÇ=ÅÉääìä~êáíó=ei= jìÅçë~ä=ã~ëí=ÅÉää== kìÅäÉ~ê=Ñ~Åíçê=ț_= kÉêîÉ=ÖêçïíÜ=Ñ~Åíçê= kçÇìä~ê=äóãéÜçÅóíÉ=éêÉÇçãáå~åÅÉ=ei= kçÇìä~ê=ëÅäÉêçëáë=ei= mêçíÉ~ëÉJ~Åíáî~íÉÇ=êÉÅÉéíçêë= píÉã=ÅÉää=Ñ~Åíçê= eÉäéÉê=qJäóãéÜçÅóíÉë= qçääJäáâÉ=êÉÅÉéíçê= qìãçìê=åÉÅêçëáë=Ñ~Åíçê=. =.

(166) =.

(167) Background. j~ëí=ÅÉääë=~êÉ=êÉÅçÖåáëÉÇ=âÉó=ÉÑÑÉÅíçê=ÅÉääë=ÇìêáåÖ=ÜóéÉêëÉåëáíáîáíó=êÉ~ÅJ íáçåë=ëìÅÜ=~ë=~å~éÜóä~ñáëI=~ëíÜã~=~åÇ=Ü~ó=ÑÉîÉêI=~åÇ=~ë=ëìÅÜ=íÜÉó=Ü~îÉ= äçåÖ= ÄÉÉå= íÜÉ= ã~áå= áåíÉêÉëí= Ñçê= ~ääÉêÖáëíëK= eçïÉîÉêI= íáãÉ= Ü~ë= éêçîÉå= ã~ëí=ÅÉääë=íç=ÄÉ=ãìäíáÑìåÅíáçå~ä=ÅÉääë=åçí=çåäó=áãéçêí~åí=áå=íÜÉ=~ÑçêÉJ ãÉåíáçåÉÇ=fÖb=ãÉÇá~íÉÇ=áããìåÉ=êÉëéçåëÉëI=Äìí=~äëç=~ë=êÉÖìä~íçêó=ÅÉääë= áå= áåå~íÉ= ~åÇ= ~ÅèìáêÉÇ= áããìåáíó= ~åÇ= íÜÉó= Ü~îÉ= ÄÉÉå= áãéäáÅ~íÉÇ= áå= î~êáçìë= éÜóëáçäçÖáÅ~ä= ~åÇ= é~íÜçäçÖáÅ~ä= ÅçåÇáíáçåëK= qÜÉáê= ÑìåÅíáçå~ä= ÇáîÉêëáíó= áë= ÇìÉ= íç= íÜÉ= êÉäÉ~ëÉ= çÑ= ëÉäÉÅíÉÇ= ãÉÇá~íçêë= Ñêçã= ~= ãóêá~Ç= çÑ= éêçáåÑä~ãã~íçêó=~åÇ=áããìåçêÉÖìä~íçêó=ãçäÉÅìäÉë=áå=êÉëéçåëÉ=íç=î~êáJ çìë=ëíáãìäáK=lìê=áåÅêÉ~ëÉÇ=âåçïäÉÇÖÉ=çÑ=íÜÉáê=Äêç~Ç=ê~åÖÉ=çÑ=áåîçäîÉJ ãÉåí=åçï=ã~âÉë=ã~ëí=ÅÉääë=çÑ=ÖÉåÉê~ä=ãÉÇáÅ~ä=áåíÉêÉëíK= =låÉ=çÑ=íÜÉ=ãçëí=áåíÉêÉëíáåÖ=~Çî~åÅÉë=áå=êÉÅÉåí=ã~ëí=ÅÉää=ÄáçäçÖó=êÉJ ëÉ~êÅÜ=áë=íÜÉ=çÄëÉêî~íáçå=íÜ~í=ã~ëí=ÅÉääë=é~êíáÅáé~íÉ=áå=íìãçìêáÖÉåÉëáëK= j~åó= èìÉëíáçåë= êÉÖ~êÇáåÖ= ã~ëí= ÅÉää= êÉÅêìáíãÉåíI= ~Åíáî~íáçå= ~åÇ= áåJ îçäîÉãÉåí=áå=íìãçìê=ÇÉîÉäçéãÉåí=ëíáää=êÉã~áå=ìå~åëïÉêÉÇK=fÇÉåíáÑáÅ~J íáçå= çÑ= ã~ëí= ÅÉää= ~Åíáî~íáçå= íêáÖÖÉêë= ã~ó= ÜáÖÜäáÖÜí= íÜÉáê= êçäÉ= áå= íÜáë= éêçÅÉëëK=qÜáë=íÜÉëáë=ÇÉëÅêáÄÉë=ëíìÇáÉë=íÜ~í=ëÜÉÇ=äáÖÜí=çå=ëçãÉ=çÑ=íÜÉëÉ= ~ëéÉÅíë=ìëáåÖ=eçÇÖâáå=äóãéÜçã~=~ë=~=ãçÇÉäK=. Mast cells qÜÉ=ÖêçìåÇïçêâ=Ñçê=íÜáë=íÜÉëáë=ï~ë=ä~áÇ=Ççïå=çåÉ=ÜìåÇêÉÇ=~åÇ=íïÉåíó= ëáñ=óÉ~êë=~Öç=ïÜÉå=íÜÉ=óçìåÖ=ãÉÇáÅ~ä=ëíìÇÉåí=m~ìä=bêäáÅÜ=ÇÉÑÉåÇÉÇ=Üáë= ÇçÅíçê~ä= íÜÉëáë= ~í= íÜÉ= jÉÇáÅ~ä= c~Åìäíó= çÑ= iáÉéòáÖ= råáîÉêëáíó= ENFK= qÜÉêÉáå=ÜÉ=ÇÉëÅêáÄÉÇ=~=ÅçååÉÅíáîÉ=íáëëìÉ=ÅÉää=ïáíÜ=~=îÉêó=ÅÜ~ê~ÅíÉêáëíáÅ= Ä~ëçéÜáäáÅ=ëí~áåáåÖ=é~ííÉêå=íÜ~í=ÜÉ=å~ãÉÇ=ã~ëí=ÅÉääK=qÜÉ=dÉêã~å=ïçêÇ= Úã~ëíÛ=ÅçãÉë=Ñêçã=íÜÉ=dêÉÉâ=µĮıĲȠı=Eã~ëíçëF=~åÇ=ãÉ~åë=ÄêÉ~ëíK=mÉêJ Ü~éë=bêäáÅÜ=éêçîáÇÉÇ=íÜÉëÉ=ÅÉääë=ïáíÜ=íÜáë=å~ãÉ=ÄÉÅ~ìëÉ=íç=íÜÉ=Üìã~å= ÉóÉ= íÜÉó= äççâÉÇ= îÉêó= ïÉääJÑÉÇ= ïáíÜ= ~ÄìåÇ~åí= Öê~åìäÉë= áå= íÜÉáê= ÅóíçJ éä~ëã= ~åÇ= íÜìë= Å~é~ÄäÉ= çÑ= éêçîáÇáåÖ= åìíêáÉåíë= íç= íÜÉáê= ÉåîáêçåãÉåí= äáâÉ=~=ÄêÉ~ëí=íç=~=ëìÅâäáåÖ=ÅÜáäÇK=qáãÉ=Ü~ë=éêçîÉå=ã~ëí=ÅÉääë=ïçêíÜó=çÑ= íÜÉáê=å~ãÉK=^äíÜçìÖÜ=íÜÉó=~êÉ=åçí=ëíçê~ÖÉ=ÅÉääë=Ñçê=åìíêáÉåíëI=íÜÉó=Å~å= éêçîáÇÉ=íÜÉáê=ëìêêçìåÇáåÖë=ïáíÜ=î~êáçìë=ÖêçïíÜ=Ñ~Åíçêë=~åÇ=ÅóíçâáåÉëK=. =. NN=.

(168) Mast cell biology qÜÉ= çêáÖáå= çÑ= ã~ëí= ÅÉääë= êÉã~áåÉÇ= çÄëÅìêÉ= Ñçê= ~äJ ãçëí= ~= ÅÉåíìêó= ~ÑíÉê= íÜÉáê= áåáíá~ä= ÇáëÅçîÉêó= Äó= bêJ äáÅÜK= kçí= ìåíáä= NVTU= ï~ë= áí= ëÜçïå= íÜ~í= áåëí~ää~íáçå= çÑ= ÄçåÉ= ã~êêçï= áåíç= ã~ëí= ÅÉää= ÇÉÑáÅáÉåí= ãáÅÉ= áåJ ÅêÉ~ëÉÇ=íÜÉ=åìãÄÉê=çÑ=íáëëìÉ=êÉëáÇÉåí=ã~ëí=ÅÉääë=EOFK= qÜáë= çÄëÉêî~íáçå= äÉÇ= íç= íÜÉ= ÅçåÅäìëáçå= íÜ~í= ã~ëí= ÅÉääë= ~êÉ= äÉìâçÅóíÉë= Éã~å~íáåÖ= Ñêçã= ëíÉã= ÅÉääë= ïáíÜáå=íÜÉ=ÄçåÉ=ã~êêçïK= H få=Üìã~åë=ã~ëí=ÅÉääë=~êÉ=ÇÉêáîÉÇ=Ñêçã=éäìêáéçíÉåí=àPQ =ÜÉã~íçJ éçáÉíáÅ= ëíÉã= ÅÉääë= ïáíÜáå= íÜÉ= ÄçåÉ= ã~êêçïK= råäáâÉ= çíÜÉê= äÉìâçÅóíÉëI= ã~ëí= ÅÉääë= Çç= åçí= ã~íìêÉ= áå= íÜÉ= ÄçåÉ= ã~êêçïI= Äìí= ê~íÜÉê= áãã~íìêÉ= H H H àPQ ÅJháí àNP =éêçÖÉåáíçêë=ÉåíÉê=~åÇ=ÅáêÅìä~íÉ=íÜÉ=ÄäççÇ=~åÇ=äóãJ éÜ~íáÅë= EPI= QFK= ^í= íÜáë= ëí~ÖÉ= íÜÉó= ÅáêÅìä~íÉ= ~ë= ãçåçåìÅäÉ~ê= äÉìâçÅóíÉë= ä~ÅâáåÖ=íÜÉáê=ÅÜ~ê~ÅíÉêáëíáÅ=Öê~åìäÉëI=Äìí=Å~å=ÄÉ=ÇáëíáåÖìáëÜÉÇ=ÜçïÉîÉê= Ñêçã=ãçåçÅóíÉë=Äó=íÜÉáê=ä~Åâ=çÑ=àNQ=ERFK=qÜÉëÉ=éêçÖÉåáíçêë=~êÉ=êÉJ ÅêìáíÉÇ= Ñêçã= íÜÉ= ÅáêÅìä~íáçå= áåíç= î~ëÅìä~êáëÉÇ= íáëëìÉë= ïÜÉêÉ= íÜÉó= ìåJ ÇÉêÖç= Ñáå~ä= ÇáÑÑÉêÉåíá~íáçå= ìåÇÉê= íÜÉ= áåÑäìÉåÅÉ= çÑ= ãáÅêçÉåîáêçåãÉåí~ä= Ñ~ÅíçêëK=qÜÉ=ã~áå=êÉÖìä~íçê=çÑ=ã~ëí=ÅÉää=Éñíê~î~ë~íáçåI=éêçäáÑÉê~íáçå=~åÇ= ÇáÑÑÉêÉåíá~íáçå= áë= ëíÉã= ÅÉää= Ñ~Åíçê= Ep`cFI= íÜÉ= äáÖ~åÇ= Ñçê= íÜÉ= ÅJâáí= íóêçJ ëáåÉ= âáå~ëÉ= êÉÅÉéíçê= ÅçåëíáíìíáîÉäó= ÉñéêÉëëÉÇ= çå= íÜÉ= ã~ëí= ÅÉää= ëìêÑ~ÅÉ= ESFK=^äíÜçìÖÜ=p`c=áë=Äó=Ñ~ê=íÜÉ=ãçëí=áãéçêí~åí=éêçãçíÉê=çÑ=ã~ëí=ÅÉää= ÇÉîÉäçéãÉåíI=ã~åó=çíÜÉê=Ñ~Åíçêë=ëìÅÜ=~ë=áåíÉêäÉìâáå=EfiFJPI=fiJQI=fiJRI= fiJSI=fiJVI=åÉêîÉ=ÖêçïíÜ=Ñ~Åíçê=EkdcFI=ÅÜÉãçâáåÉë=~åÇ=êÉíáåçáÇëI=Ü~îÉ= ÄÉÉå=ëìÖÖÉëíÉÇ=íç=ÅçåíêáÄìíÉ=ÉáíÜÉê=ëóåÉêÖáëíáÅ~ääó=çê=~åí~ÖçåáëíáÅ~ääó=áå= ~=ÅçãéäÉñ=åÉíïçêâ=ETJNOFK= aìêáåÖ= íÜÉ= ã~íìê~íáçå= éêçÅÉëë= ã~ëí= ÅÉääë= ~ÅèìáêÉ= íÜÉáê= íóéáÅ~ä= Öê~åìä~íÉÇ=ãçêéÜçäçÖó=~åÇ=ÄÉÖáå=íç=ÉñéêÉëë=íÜÉ=ÜáÖÜJ~ÑÑáåáíó=êÉÅÉéíçê= Ñçê= fÖb= EcÅİofFI= ïÜáÅÜ= áë= çåÉ= çÑ= íÜÉ= Åä~ëëáÅ= ã~êâÉêë= Ñçê= íÜÉëÉ= ÅÉääëK= píçêÉÇ= áå= íÜÉ= Öê~åìäÉë= ~êÉ= éêÉJÑçêãÉÇ= ãÉÇá~íçêë= ëìÅÜ= ~ë= Üáëí~ãáåÉI= éêçíÉçÖäóÅ~åëI=åÉìíê~ä=éêçíÉ~ëÉë=~åÇ=ÅóíçâáåÉëK=fí=áë=íÜÉ=~ÅáÇáÅ=å~íìêÉ=çÑ= íÜÉ= éêçíÉçÖäóÅ~åë= íÜ~í= ~ääçïë= ã~ëí= ÅÉääë= íç= ëí~áå= ãÉí~ÅÜêçã~íáÅ~ääó= ïáíÜ=ÅÉêí~áå=Ä~ëáÅ=ÇóÉëI=áKÉ=íÜÉ=ÇóÉ=ÅÜ~åÖÉë=ÅçäçìêK=qÜáë=ï~ë=íÜÉ=éêçéJ Éêíó=bäêáÅÜ=ëç=ÉäÉÖ~åíäó=ÇÉëÅêáÄÉÇK= j~íìêÉ= ã~ëí= ÅÉääë= êÉëáÇÉ= áå= ÅçååÉÅíáîÉ= íáëëìÉ= íÜêçìÖÜçìí= íÜÉ= ÄçÇó= ~åÇ=áå=Åçåíê~ëí=íç=çíÜÉê=ÅÉääë=çÑ=Ü~Éã~íçéçáÉíáÅ=çêáÖáå=Å~å=ÄÉ=îÉêó=äçåÖJ äáîÉÇ= ~åÇ= êÉí~áå= íÜÉáê= éêçäáÑÉê~íáîÉ= ~Äáäáíó= ENPI= NQFK= qÜÉó= ~êÉ= é~êíáÅìJ ä~êäó= ÑêÉèìÉåí= ~êçìåÇ= ÄäççÇ= îÉëëÉäëI= áå= ÅäçëÉ= éêçñáãáíó= íç= éÉêáéÜÉê~ä= åÉêîÉë= ~åÇ= ÄÉåÉ~íÜ= ÉéáíÜÉäá~ä= ëìêÑ~ÅÉë= ÉñéçëÉÇ= íç= íÜÉ= ÉñíÉêå~ä= ÉåîáJ êçåãÉåíI=ëìÅÜ=~ë=íÜçëÉ=áå=êÉëéáê~íçêó=~åÇ=Ö~ëíêçáåíÉëíáå~ä=íê~Åí=~åÇ=ëâáå= ENQJNSFK=. NO=. =.

(169) Mast cell phenotypes are a result of their local environment qÜÉ= íáëëìÉ= ãáÅêçÉåîáêçåãÉåí= Ü~ë= ~= éêçÑçìåÇ= áãé~Åí= çå= íÜÉ= ÇÉîÉäçéJ ãÉåí=~åÇ=ëìÄëÉèìÉåí=éÜÉåçíóéáÅ=ÉñéêÉëëáçå=çÑ=ã~ëí=ÅÉääëK=aÉéÉåÇáåÖ= çå=ÇáÑÑÉêÉåÅÉë=áå=íÜÉ=ÅóíçâáåÉ=ãáäáÉì=~åÇ=ÅÉää=áåíÉê~Åíáçåë=çÅÅìêáåÖ=áå= î~êáçìë=íáëëìÉëI=ã~ëí=ÅÉääë=ÇÉîÉäçé=ÜÉíÉêçÖÉåÉçìë=éÜÉåçíóéÉë=~åÇ=ÑìåÅJ íáçå~ä=ÅÜ~ê~ÅíÉêáëíáÅëK= qÜÉ=ÅçåÅÉéí=çÑ= ã~ëí=ÅÉää=ÜÉíÉêçÖÉåÉáíó=ï~ë= Ñáêëí= êÉÅçÖåáëÉÇ=Äó=båJ ÉêÄ®Åâ=ïÜÉå=ÜÉ=Åçãé~êÉÇ=ã~ëí=ÅÉääë=éêÉëÉåí=áå=êçÇÉåí=ÅçååÉÅíáîÉ=íáëJ ëìÉ=ïáíÜ=íÜçëÉ=áå=áåíÉëíáå~ä=ãìÅçë~I=~åÇ=ÇáëÅçîÉêÉÇ=íÜ~í=íÜÉëÉ=ÇáÑÑÉêÉåí= éçéìä~íáçåë=ÉñÜáÄáíÉÇ=î~êá~íáçåë=áå=ëí~áåáåÖ=éêçéÉêíáÉëK=qÜÉ=íïç=Öêçìéë= ïÉêÉ=ÇÉåçíÉÇ=ÅçååÉÅíáîÉ=íáëëìÉ=ã~ëí=ÅÉääë=E`qj`F=~åÇ=ãìÅçë~ä=ã~ëí= ÅÉääë=Ejj`F=~ÅÅçêÇáåÖäó=ENTFK=qÜÉáê=ÜáëíçÅÜÉãáÅ~ä=ÇáÑÑÉêÉåÅÉë=~êÉ=ÇìÉ= íç= íÜÉ= ÜÉé~êáå= ÖäóÅçë~ãáåçÖäóÅ~åJêáÅÜ= éêçíÉçÖäóÅ~åë= áå= `qj`ë= ÅçãJ é~êÉÇ= ïáíÜ= ãçåçJ= ~åÇ= ÇáëìäéÜ~íÉÇ= ÅÜçåÇêçáíáå= ëìäéÜ~íÉ= ÖäóÅçë~ãáJ åçÖäóÅ~åë=äáåâÉÇ=íç=íÜÉ=éêçíÉçÖäóÅ~åë=áå=jj`ë=ENUI=NVFK= få= íÜÉ= Å~ëÉ= çÑ= Üìã~å= ã~ëí= ÅÉääëI= íÜÉëÉ= ÜáëíçÅÜÉãáÅ~ä= ÇáëíáåÅíáçåë= Å~ååçí= ÄÉ= ã~ÇÉ= ÇìÉ= íç= íÜÉ= éêÉëÉåÅÉ= çÑ= ÜÉé~êáå= áå= ~ää= ã~ëí= ÅÉääëK= aÉJ ëéáíÉ= íÜáë= íÜÉó= Å~å= ëíáää= ÄÉ= ÇáîáÇÉÇ= áåíç= íïç= ëìÄÖêçìéë= Ä~ëÉÇ= çå= íÜÉáê= äçÅ~íáçå= ~åÇ= ÇáÑÑÉêÉåÅÉë= áå= Öê~åìäÉ= ÅçåíÉåí= çÑ= éêçíÉ~ëÉëK= låÉ= éçéìä~J íáçå= Åçåí~áåë= ÄçíÜ= ÅÜóã~ëÉ= ~åÇ= íêóéí~ëÉ= áå= íÜÉ= Öê~åìäÉë= ~åÇ= áë= íÜìë= ÇÉëáÖå~íÉÇ= j`qÌ= ïÜÉêÉ~ë= íÜÉ= êÉã~áåáåÖ= éçéìä~íáçå= ëíçêÉë= çåäó= íêóéJ í~ëÉ=~åÇ=áë=~ÄÄêÉîá~íÉÇ=~ÅÅçêÇáåÖäó=~ë=j`q=EOMFK=få=íÉêãë=çÑ=íáëëìÉ=äçJ Å~äáë~íáçåI= j`q`= éêÉÇçãáå~íÉ= áå= íÜÉ= ëâáå= ~åÇ= áåíÉëíáå~ä= ëìÄãìÅçë~I= ïÜÉêÉ~ë= j`q= ~êÉ= íÜÉ= éêÉÇçãáå~åí= ëìÄíóéÉ= áå= íÜÉ= äìåÖ= ~åÇ= áåíÉëíáå~ä= ä~ãáå~= éêçéêá~K= qÜáë= ÇáëíêáÄìíáçå= ëìÖÖÉëíë= íÜ~í= j`q`= ~åÇ= j`q= ~êÉ= íÜÉ=~å~äçÖìÉë=íç=êçÇÉåí=`qj`=~åÇ= jj`= êÉëéÉÅíáîÉäó= EONI= OOFK= få= ~ÇJ Çáíáçå= íç= î~êá~íáçåë= áå= éêçíÉ~ëÉëI= T-cell íÜÉëÉ= íïç= ëìÄÖêçìéë= ÇáÑÑÉê= Ä~ëÉÇ= SCF çå=íÜÉáê=ÅóíçâáåÉ=ÅçåíÉåíI=ïáíÜ=fiJ Q=éêÉëÉåí=áå=ÄçíÜ=ïÜÉêÉ~ë=fiJR=~åÇ= fiJS=~êÉ=êÉëíêáÅíÉÇ=íç=íÜÉ=j`q=EOPFK= ^ë=ãÉåíáçåÉÇ=~ÄçîÉI=íÜÉ=åçêã~ä= MCTC MCT ÇÉîÉäçéãÉåí= çÑ= ~ää= íáëëìÉ= ã~ëí= ÅÉää= éçéìä~íáçåë= áå= îáîç= êÉèìáêÉë= p`cK= Figure 1. Mast cell extravasation and ^ÇÇáíáçå~ä= Ñ~Åíçêë= ÇÉêáîÉÇ= Ñêçã= q= maturation is dependent on SCF. PresäóãéÜçÅóíÉë= ~êÉ= åÉÉÇÉÇ= Ñçê= íÜÉ= ence of SCF alone promotes developÇÉîÉäçéãÉåí= çÑ= íÜÉ= ãìÅçë~ä= ëìÄJ ment of MCTC. Additional T-cell factors íóéÉ=áå=ÄçíÜ=ãáÅÉ=~åÇ=Üìã~åë=Äìí= are required for differentiation into åçí= Ñçê= ÅçååÉÅíáîÉ= íáëëìÉ= ã~ëí= ÅÉää= MCT . =. NP=.

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