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Analysis of 2-visit COPDgene data with consideration of missing data

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❆◆❆▲❨❙■❙ ❖❋ ✷✲❱■❙■❚ ❈❖P❉●❊◆❊ ❉❆❚❆ ❲■❚❍ ❈❖◆❙■❉❊❘❆❚■❖◆ ❖❋ ▼■❙❙■◆● ❉❆❚❆ ❜② ▼❆❘❨ ▼✳ ▼❖❘❘❖❲ ❇✳❆✳✱ ▲❡✇✐s ❛♥❞ ❈❧❛r❦ ❈♦❧❧❡❣❡✱ ✶✾✽✼ ❆ t❤❡s✐s s✉❜♠✐tt❡❞ t♦ t❤❡ ❋❛❝✉❧t② ♦❢ t❤❡ ●r❛❞✉❛t❡ ❙❝❤♦♦❧ ♦❢ t❤❡ ❯♥✐✈❡rs✐t② ♦❢ ❈♦❧♦r❛❞♦ ✐♥ ♣❛rt✐❛❧ ❢✉❧✜❧❧♠❡♥t ♦❢ t❤❡ r❡q✉✐r❡♠❡♥ts ❢♦r t❤❡ ❞❡❣r❡❡ ♦❢ ▼❛st❡r ♦❢ ❙❝✐❡♥❝❡ ❇✐♦st❛t✐st✐❝s Pr♦❣r❛♠ ✷✵✶✻

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❚❤✐s t❤❡s✐s ❢♦r t❤❡ ▼❛st❡r ♦❢ ❙❝✐❡♥❝❡ ❞❡❣r❡❡ ❜② ▼❛r② ▼✳ ▼♦rr♦✇ ❤❛s ❜❡❡♥ ❛♣♣r♦✈❡❞ ❢♦r t❤❡ ❇✐♦st❛t✐st✐❝s Pr♦❣r❛♠ ❜② ●❛r② ❑✳ ●r✉♥✇❛❧❞✱ ❈❤❛✐r ▼❛tt❤❡✇ ❏✳ ❙tr❛♥❞✱ ❆❞✈✐s♦r ❊❧✐③❛❜❡t❤ ❏✉❛r❡③✲❈♦❧✉♥❣❛ ❉❛t❡ ✺✴✷✵✴✷✵✶✻ ✐✐

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▼♦rr♦✇✱ ▼❛r② ▼✳ ✭▼✳❙✳✱ ❇✐♦st❛t✐st✐❝s✮ ❆♥❛❧②s✐s ♦❢ ✷✲✈✐s✐t ❈❖P❉●❡♥❡ ❉❛t❛ ✇✐t❤ ❈♦♥s✐❞❡r❛t✐♦♥ ♦❢ ▼✐ss✐♥❣ ❉❛t❛ ❚❤❡s✐s ❞✐r❡❝t❡❞ ❜② ❆ss♦❝✐❛t❡ Pr♦❢❡ss♦r ▼❛tt❤❡✇ ❏✳ ❙tr❛♥❞ ❆❇❙❚❘❆❈❚ ▼✐ss✐♥❣ ❞❛t❛ ✐s ❛ ❝♦♠♠♦♥ ♣r♦❜❧❡♠ ✐♥ ❧♦♥❣✐t✉❞✐♥❛❧ st✉❞✐❡s✳ ■❣♥♦r✐♥❣ t❤❡ ✐ss✉❡ ❛♥❞ ✐♠✲ ♣❧❡♠❡♥t✐♥❣ ❛ ❝♦♠♣❧❡t❡✲❝❛s❡ ❛♥❛❧②s✐s ❝❛♥ ❧❡❛❞ t♦ ❡st✐♠❛t❡s ✇❤✐❝❤ ❛r❡ ❜✐❛s❡❞ ♦r ❝♦♥✜❞❡♥❝❡ ✐♥t❡r✈❛❧s ✇✐t❤ ❛♥ ✐♥❛❝❝✉r❛t❡ ❝♦✈❡r❛❣❡ r❛t❡✳ ❚✇♦ ❛♥❛❧②t✐❝❛❧ t❡❝❤♥✐q✉❡s ✇❤✐❝❤ ❝♦♥s✐❞❡r ❜♦t❤ t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❛♥❞ s✉r✈✐✈❛❧ ❛s♣❡❝ts ♦❢ t❤❡ ❞❛t❛ ❛r❡ ❥♦✐♥t ❛♥❞ t✇♦✲♣❛rt ♠♦❞❡❧s✳ ❇♦t❤ ♦❢ t❤❡s❡ ♠❡t❤♦❞s ❛ss♦❝✐❛t❡ ❛ ❧♦♥❣✐t✉❞✐♥❛❧ ❝♦♠♣♦♥❡♥t ♦❢ t❤❡ ♠♦❞❡❧ ✇✐t❤ ❛ s✉r✈✐✈❛❧ ❝♦♠♣♦♥❡♥t t❤r♦✉❣❤ s❤❛r❡❞ r❛♥❞♦♠ ❡✛❡❝ts✳ ❚❤✐s t❤❡s✐s ❛✐♠s t♦ ✉♥❞❡rst❛♥❞ ❤♦✇ t❤✐s ❛ss♦❝✐❛t✐♦♥ ✐♠♣❛❝ts t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❡st✐♠❛t❡s ❢♦r ❛ ❞❛t❛s❡t ✇✐t❤ ❧✐♠✐t❡❞ ❧♦♥❣✐t✉❞✐♥❛❧ ♦❜s❡r✈❛t✐♦♥s✳ ❚❤❡ ❢♦r♠ ❛♥❞ ❝♦♥t❡♥t ♦❢ t❤✐s ❛❜str❛❝t ❛r❡ ❛♣♣r♦✈❡❞✳ ■ r❡❝♦♠♠❡♥❞ ✐ts ♣✉❜❧✐❝❛t✐♦♥✳ ❆♣♣r♦✈❡❞✿ ▼❛tt❤❡✇ ❏✳ ❙tr❛♥❞ ✐✐✐

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❉❊❉■❈❆❚■❖◆

❚❤✐s t❤❡s✐s ✐s ❞❡❞✐❝❛t❡❞ t♦ t❤❡ ♠❡♠♦r② ♦❢ ♠② ❢❛t❤❡r✱ ❉r✳ ❆rt❤✉r ❏✳ ❑✐❞♥❛②✱ ❢♦r ❛❧❧ ♦❢ ❤✐s ❧♦✈❡ ❛♥❞ ❢♦r ❣❡tt✐♥❣ ♠❡ ✐♥t❡r❡st❡❞ ✐♥ s❝✐❡♥❝❡ ✐♥ t❤❡ ✜rst ♣❧❛❝❡✳

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❆❈❑◆❖❲▲❊❉●❊▼❊◆❚❙ ■ ✇♦✉❧❞ ❧✐❦❡ t♦ t❤❛♥❦ ♠② ❛❞✈✐s♦r✱ ❉r✳ ▼❛tt❤❡✇ ❙tr❛♥❞✱ ❢♦r ❤✐s ❣❡♥❡r♦s✐t② ✐♥ s❤❛r✐♥❣ ❤✐s ❞❛t❛ ❛♥❞ ❛❧❧♦✇✐♥❣ ♠❡ t♦ ❜✉✐❧❞ ♦♥ ❤✐s ✐♥✐t✐❛❧ ✇♦r❦✳ ❍✐s ❣✉✐❞❛♥❝❡✱ ❡♥❝♦✉r❛❣❡♠❡♥t ❛♥❞ ♣❛t✐❡♥❝❡ t❤r♦✉❣❤♦✉t t❤❡ ❡♥t✐r❡ ♣r♦❝❡ss ✇❛s ❣r❡❛t❧② ❛♣♣r❡❝✐❛t❡❞✳ ■ ❛❧s♦ ✇❛♥t t♦ ❡①♣r❡ss ♠② s✐♥❝❡r❡st ❣r❛t✐t✉❞❡ t♦ ❉r✳ ●❛r② ●r✉♥✇❛❧❞ ❛♥❞ ❉r✳ ❊❧✐③❛❜❡t❤ ❏✉❛r❡③✲❈♦❧✉♥❣❛✱ ❢♦r t❤❡✐r ❝♦♥tr✐❜✉t✐♦♥s ❛s ❝♦♠♠✐tt❡❡ ♠❡♠❜❡rs✳ ❚❤❡✐r ❡①t❡♥s✐✈❡ ❦♥♦✇❧❡❞❣❡ ❛♥❞ ❡①♣❡rt✐s❡ ❤❡❧♣❡❞ ❣✉✐❞❡ t❤❡ ♣r♦❝❡ss ❛♥❞ ✇❛s ✐♥✈❛❧✉❛❜❧❡✳ ▲❛st❧②✱ t❤❛♥❦ ②♦✉ t♦ ♠② ❤✉s❜❛♥❞✱ ▼✐❝❤❛❡❧✱ ❢♦r ❤✐s s✉♣♣♦rt ❛♥❞ ❡♥❝♦✉r❛❣❡♠❡♥t ❞✉r✐♥❣ t❤❡ ♠❛♥② ❧♦♥❣ ❤♦✉rs s♣❡♥t ❝♦♠♣❧❡t✐♥❣ ♠② ❞❡❣r❡❡✳ ✈

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❚❆❇▲❊ ❖❋ ❈❖◆❚❊◆❚❙ ❈❍❆P❚❊❘ ■✳ ■◆❚❘❖❉❯❈❚■❖◆ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✶ ■✳✶ ▼♦t✐✈❛t✐♦♥ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✶ ■✳✷ ❇❛❝❦❣r♦✉♥❞ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✷ ■✳✸ ◗✉❡st✐♦♥ ♦❢ ■♥t❡r❡st ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✸ ■■✳ ❉❆❚❆ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✹ ■■✳✶ ●♦❧❞ ❙t❛❣❡ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✹ ■■✳✷ ❆❞❞✐t✐♦♥❛❧ ❍❡❛❧t❤ ■♥❢♦r♠❛t✐♦♥ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✹ ■■■✳ ▲❖◆●■❚❯❉■◆❆▲ ❈❖◆❙■❉❊❘❆❚■❖◆❙ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✼ ■■■✳✶ ❙♦❢t✇❛r❡ ❈❤♦✐❝❡ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✼ ■■■✳✷ ❉❡✈❡❧♦♣♠❡♥t ♦❢ ❛ ❘❛♥❞♦♠ ❙❧♦♣❡ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✼ ■■■✳✸ ❉❛t❛ ✇✐t❤ ❊①❝❡ss ❩❡r♦s ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✽ ■❱✳ ❏❖■◆❚ ▼❖❉❊▲ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✾ ■❱✳✶ ❙❤❛r❡❞ ❘❛♥❞♦♠ ■♥t❡r❝❡♣t ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✾ ■❱✳✷ ❆❧t❡r♥❛t✐✈❡ P❛r❛♠❡t❡r✐③❛t✐♦♥ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✶✵ ■❱✳✸ ❈♦♠♣❛r✐s♦♥ ♦❢ ❋✐①❡❞✲❊✛❡❝t ❚❡r♠ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✶✷ ❱✳ ❚❲❖✲P❆❘❚ ▼❖❉❊▲ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✶✹ ❱✳✶ ◆♦t❛t✐♦♥ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✶✹ ❱✳✷ ▼♦❞❡❧ ❘❡s✉❧ts ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✶✺ ❱■✳ ❉■❙❈❯❙❙■❖◆ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✶✽ ❱■✳✶ ▼♦❞❡❧ ❈♦♠♣❛r✐s♦♥ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✶✽ ❱■✳✷ ❆♣♣❧✐❝❛t✐♦♥ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✶✾ ❘❊❋❊❘❊◆❈❊❙ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✷✵ ❆PP❊◆❉■❳ ✈✐

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❆✳ ❙❆❙ ❝♦❞❡ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✷✶ ❆✳✶ ❏♦✐♥t ▼♦❞❡❧ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✷✶ ❆✳✷ ❚✇♦✲♣❛rt ▼♦❞❡❧ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✷✷

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▲■❙❚ ❖❋ ❚❆❇▲❊❙ ❚❆❇▲❊ ■❱✳✶ ●❛♠♠❛ ❝♦♥✈❡r❣❡♥❝❡ ♦❢ t❤❡ ❥♦✐♥t ♠♦❞❡❧ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✶✶ ■❱✳✷ ▲♦♥❣✐t✉❞✐♥❛❧ ♣❛r❛♠❡t❡r ❝♦♠♣❛r✐s♦♥ ❜❡t✇❡❡♥ s✐♠♣❧❡ ❛♥❞ ❥♦✐♥t ♠♦❞❡❧s ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✶✸ ■❱✳✸ ❆✈❡r❛❣❡ ❋❊❱✶ r❡s✉❧ts ❜② st❛❣❡ ❢♦r ❜♦t❤ s✐♠♣❧❡ ❛♥❞ ❥♦✐♥t ♠♦❞❡❧s ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✶✸ ❱✳✶ ▲♦♥❣✐t✉❞✐♥❛❧ ♣❛r❛♠❡t❡r ❝♦♠♣❛r✐s♦♥ ❜❡t✇❡❡♥ s✐♠♣❧❡ ❛♥❞ t✇♦✲♣❛rt ♠♦❞❡❧s ✳ ✳ ✳ ✳ ✳ ✶✼ ❱✳✷ ❆✈❡r❛❣❡ ❋❊❱✶ r❡s✉❧ts ❜② st❛❣❡ ❢♦r ❜♦t❤ s✐♠♣❧❡ ❛♥❞ t✇♦✲♣❛rt ♠♦❞❡❧s ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✶✼ ✈✐✐✐

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▲■❙❚ ❖❋ ❋■●❯❘❊❙ ❋■●❯❘❊ ■■✳✶ ❙✉❜❥❡❝t st❛t✉s ❛❢t❡r ✜✈❡ ②❡❛rs ❜❛s❡❞ ♦♥ ❜❛s❡❧✐♥❡ ●❖▲❉ st❛❣❡✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✺ ■■✳✷ ❑❛♣❧❛♥✲▼❡✐❡r ❙✉r✈✐✈❛❧ ❈✉r✈❡ ❢♦r ●❖▲❉ ❙t❛❣❡ ■ ✲ ■❱✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✻ ■■✳✸ ❋❊❱✶ ❛t ❡❛❝❤ ✈✐s✐t ❜② ●❖▲❉ st❛❣❡ ❛♥❞ s❡✈❡r❡ ❡①❛❝❡r❜❛t✐♦♥s st❛t✉s✳ ✳ ✳ ✳ ✳ ✳ ✳ ✳ ✻ ✐①

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❈❍❆P❚❊❘ ■ ■◆❚❘❖❉❯❈❚■❖◆ ■✳✶ ▼♦t✐✈❛t✐♦♥ ■♥ ❧♦♥❣✐t✉❞✐♥❛❧ st✉❞✐❡s ✇❤❡r❡ r❡♣❡❛t❡❞ ♦❜s❡r✈❛t✐♦♥s ♦❝❝✉r ♦♥ t❤❡ s❛♠❡ s✉❜❥❡❝t✱ ♠✐ss✐♥❣ ❞❛t❛ ✐s ♦❢t❡♥ t❤❡ ♥♦r♠✳ ❆s ✐♥❝♦♠♣❧❡t❡ r❡❛❞✐♥❣s ❤❛✈❡ t❤❡ ♣♦t❡♥t✐❛❧ t♦ ✐♥❝r❡❛s❡ ❜✐❛s ❛♥❞ ♣r♦✈✐❞❡ ✐♥❛❝❝✉r❛t❡ ♠❡❛s✉r❡s ♦❢ ✉♥❝❡rt❛✐♥t② ❛r♦✉♥❞ ❡st✐♠❛t❡s✱ ❛♥❛❧②③✐♥❣ ❞❛t❛s❡ts ✇✐t❤ ♠✐ss✲ ✐♥❣ ✈❛❧✉❡s ✐s t❤❡ t♦♣✐❝ ♦❢ ♠✉❝❤ r❡s❡❛r❝❤✳ ▲✐tt❧❡ ❛♥❞ ❘✉❜✐♥ ❛r❡ ♣✐♦♥❡❡rs ✐♥ t❤✐s ❛r❡❛✱ ❛♥❞ t❤❡✐r ❡✛♦rt ❤❛s ❧❡❞ t♦ ❛ ❝♦♠♠♦♥ t❡r♠✐♥♦❧♦❣② ✉s❡❞ t♦ ❝❧❛ss✐❢② ♠✐ss✐♥❣ ✈❛❧✉❡s ❜❛s❡❞ ♦♥ t❤❡ r❡❛s♦♥ t❤❡ ✈❛❧✉❡ ✐s ♠✐ss✐♥❣ ✭P✐❣♦tt✱ ✷✵✵✶✮✳ ❚❤❡ ✜rst ❝❧❛ss✐✜❝❛t✐♦♥✱ ▼✐ss✐♥❣ ❈♦♠♣❧❡t❡❧② ❆t ❘❛♥❞♦♠ ✭▼❈❆❘✮✱ ✐s r❛r❡❧② s❡❡♥ ✐♥ ♣r❛❝t✐❝❡ ❛s t❤❡ ♣r♦❜❛❜✐❧✐t② t❤❛t t❤❡ ✈❛❧✉❡ ✐s ♠✐ss✐♥❣ ✐s ♥♦t r❡❧❛t❡❞ t♦ ❛♥②t❤✐♥❣ ❦♥♦✇♥ ♦r ✉♥❦♥♦✇♥✳ ❚❤❡ s❡❝♦♥❞ ❝❧❛ss✐✜❝❛t✐♦♥✱ ▼✐ss✐♥❣ ❆t ❘❛♥❞♦♠ ✭▼❆❘✮✱ ❛❧❧♦✇s t❤❡ ♠✐ss✐♥❣ r❡s♣♦♥s❡ t♦ ❜❡ r❡❧❛t❡❞ t♦ ❛ ♣❛rt✐❝✉❧❛r ✈❛r✐❛❜❧❡✱ ❜✉t ✐t ❝❛♥♥♦t ❜❡ r❡❧❛t❡❞ t♦ t❤❡ ✈❛❧✉❡ ♦❢ t❤❡ ♠✐ss✐♥❣ r❡s♣♦♥s❡✳ ❋♦r ❡①❛♠♣❧❡✱ ✐♥ ❛ s❝❤♦♦❧ ❛❞♠✐♥✐st❡r❡❞ s✉r✈❡② ❧♦♦❦✐♥❣ ❛t ❝❤✐❧❞r❡♥ ❧✐✈✐♥❣ ✇✐t❤ ❛st❤♠❛✱ ②♦✉♥❣❡r ❝❤✐❧❞r❡♥ ♠✐❣❤t ❤❛✈❡ tr♦✉❜❧❡ ✜❧❧✐♥❣ ♦✉t ❛❧❧ t❤❡ q✉❡st✐♦♥s ❛♥❞ s♦ ♠✐❣❤t ♠✐ss r❡❝♦r❞✐♥❣ t❤❡✐r s②♠♣t♦♠ s❡✈❡r✐t②✳ ❚❤❡ ♠✐ss✐♥❣ ✈❛❧✉❡ ❢♦r s②♠♣t♦♠ s❡✈❡r✐t② ✐s t❤✉s r❡❧❛t❡❞ t♦ ❛❣❡✱ ❜✉t ✐t ✐s ♥♦t r❡❧❛t❡❞ t♦ t❤❡ s❡✈❡r✐t② ♦❢ t❤❡ ❝❤✐❧❞✬s ❛st❤♠❛✳ ■♥ t❤❡ ❧❛st ❝❛t❡❣♦r②✱ ▼✐ss✐♥❣ ◆♦t ❆t ❘❛♥❞♦♠ ✭▼◆❆❘✮✱ ❛ ♠✐ss✐♥❣ r❡s♣♦♥s❡ ✐s ❜♦t❤ r❡❧❛t❡❞ t♦ t❤❡ r❡❛s♦♥ ✐t ✐s ♠✐ss✐♥❣ ❛♥❞ ❛❧s♦ ✉♥♦❜s❡r✈❡❞✳ ❋♦r ❡①❛♠♣❧❡✱ ❝❤✐❧❞r❡♥ ✇❤♦ ♠✐ss s❝❤♦♦❧ ❜❡❝❛✉s❡ ♦❢ ❛♥ ❛st❤♠❛ ❡♣✐s♦❞❡ ✇♦✉❧❞ ♥♦t ❜❡ ❛✈❛✐❧❛❜❧❡ t♦ ✜❧❧ ♦✉t ❛ ❤❡❛❧t❤ s✉r✈❡②✳ ■♥ t❤✐s ❝❛s❡✱ ❛ ♠✐ss✐♥❣ ✈❛❧✉❡ ❢♦r s②♠♣t♦♠ s❡✈❡r✐t② ✇♦✉❧❞ ❜❡ ❞✐r❡❝t❧② r❡❧❛t❡❞ t♦ t❤❡ s❡✈❡r✐t② ♦❢ ❛ ❝❤✐❧❞✬s ❛st❤♠❛ s②♠♣t♦♠s✳ ❚❤✐s t②♣❡ ♦❢ ❛❜s❡♥❝❡ ❤❛s t❤❡ ♣♦t❡♥t✐❛❧ t♦ ❜✐❛s r❡s✉❧ts ❛♥❞ ✐s t❡r♠❡❞ ♥♦♥✐❣♥♦r❛❜❧❡ ♦r ▼◆❆❘✳ ▼❛♥② ❝❧✐♥✐❝❛❧ tr✐❛❧s ✉s❡ ❛ ❝♦♠♣❧❡t❡ ❝❛s❡ ❛♥❛❧②s✐s✱ ❛♥❞ t❤✐s ❛♣♣r♦❛❝❤ ♣r♦✈✐❞❡s r❡s✉❧ts t❤❛t ❛r❡ ❣❡♥❡r❛❧✐③❛❜❧❡ t♦ t❤❡ ❣❡♥❡r❛❧ ♣♦♣✉❧❛t✐♦♥ ♣r♦✈✐❞❡❞ t❤❡ ❞❛t❛ ✐s ▼❈❆❘✳ ❆s t❤✐s ✐s ♦❢t❡♥ ♥♦t t❤❡ ❝❛s❡✱ t❤❡ ✉s❡ ♦❢ ❝♦♠♣❧❡t❡ ❝❛s❡ ❛♥❛❧②s✐s ❤❛s ❦♥♦✇♥ ❞r❛✇❜❛❝❦s✳ ❖t❤❡r ❛♣♣r♦❛❝❤❡s t♦ ❛❝❝♦✉♥t ❢♦r ♠✐ss✐♥❣ ❞❛t❛ ✐♥❝❧✉❞❡ ▲❛st ❖❜s❡r✈❛t✐♦♥ ❈❛rr✐❡❞ ❋♦r✇❛r❞ ✭▲❖❈❋✮ ❛♥❞ s✐♠♣❧❡ ❢♦r♠s ♦❢ ✐♠♣✉t❛t✐♦♥✳ ❚❤❡s❡ ♠❡t❤♦❞s ❛r❡ r❡❧❛t✐✈❡❧② ❡❛s② t♦ ❡♠♣❧♦② ❜✉t ❛r❡ ♦❢t❡♥ ❛♣♣❧✐❡❞ ✇✐t❤♦✉t ❝♦♥s✐❞❡r❛t✐♦♥ ♦❢ ❤♦✇ t❤❡✐r ✐♠♣❧❡♠❡♥t❛t✐♦♥ ♠✐❣❤t ✐♠♣❛❝t ✜♥❛❧ r❡s✉❧ts✳ ❆❧t❡r♥❛t✐✈❡❧②✱ ❧✐♥❡❛r ♠✐①❡❞ ♠♦❞❡❧s ❛❝❝♦✉♥t ❢♦r ♣❛rt✐❛❧ r❡❝♦r❞s ❛♥❞ ✐t ❝❛♥ ❜❡ s❤♦✇♥ t❤❛t ✐❢ ❞❛t❛ ✐s ▼✐ss✐♥❣ ✶

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❛t ❘❛♥❞♦♠✱ t❤❡✐r r❡s✉❧ts ❛r❡ ♠♦r❡ ❝♦♥s✐st❡♥t t❤❛♥ ❛♥ ❛♥❛❧②s✐s ✉s✐♥❣ s✐♠♣❧❡ ✐♠♣✉t❛t✐♦♥ t❡❝❤♥✐q✉❡s ✭▼♦❧❡♥❜❡r❣❤s ❡t ❛❧✳✱ ✷✵✵✹✮✳ ▼✐①❡❞ ♠♦❞❡❧s ❤❛✈❡ t❤❡ ❛❞❞❡❞ ❛❞✈❛♥t❛❣❡ ♦❢ ❜❡✐♥❣ r❡❣✉❧❛r❧② ✉t✐❧✐③❡❞ ✐♥ ❝♦♠♠♦♥❧② ❛✈❛✐❧❛❜❧❡ s♦❢t✇❛r❡ ♣❛❝❦❛❣❡s✳ ❆ ❧✐♠✐t❛t✐♦♥ ♦❢ t❤❡ ♠✐①❡❞ ♠♦❞❡❧ ❛♣♣r♦❛❝❤ ✐s t❤❛t ♠✐ss✐♥❣ ❞❛t❛ ✐s ❛ss✉♠❡❞ t♦ ❜❡ ♥♦♥✲✐♥❢♦r♠❛t✐✈❡ ♦r ▼❆❘✳ ❆s ✐t ✐s ✐♠♣♦ss✐❜❧❡ t♦ t❡st ✇❤❡t❤❡r ❞❛t❛ ✐s ▼✐ss✐♥❣ ◆♦t ❆t ❘❛♥❞♦♠✱ ♠✐①❡❞ ♠♦❞❡❧s ❛r❡ ♦❢t❡♥ ❡♠♣❧♦②❡❞ ✉♥❞❡r t❤❡ ❤♦♣❡ t❤❛t ❞❛t❛ ✐s ▼❆❘ ❛♥❞ ♥♦ ❢♦r♠❛❧ ❛♥❛❧②s✐s ♦❢ t❤✐s ❛ss✉♠♣t✐♦♥ ✐s ♣❡r❢♦r♠❡❞✳ ❆♥❛❧②t✐❝❛❧ t❡❝❤♥✐q✉❡s ❞❡✈❡❧♦♣❡❞ t♦ ❛❞❞r❡ss ♠✐ss✐♥❣ ❞❛t❛ ❞♦ ❡①✐st ❛♥❞ ✐♥❝❧✉❞❡ s❡❧❡❝t✐♦♥ ❛♥❞ ♣❛tt❡r♥✲♠✐①t✉r❡ ♠♦❞❡❧s ✭❑❡♥✇❛r❞✱ ✶✾✾✽✮✳ ❚❤❡s❡ ♠❡t❤♦❞s r❡q✉✐r❡ ❛ss✉♠♣t✐♦♥s ❛❜♦✉t t❤❡ ❞✐str✐❜✉t✐♦♥ ♦❢ t❤❡ ♠✐ss✐♥❣ ❞❛t❛ ❛♥❞ ✐♥❝r❡❛s❡ t❤❡ ❝♦♠♣❧❡①✐t② ♦❢ t❤❡ ❛♥❛❧②s✐s s✐❣♥✐✜❝❛♥t❧②✳ ❱❛r✐♦✉s ❛✉t❤♦rs ✭❲✉ ❡t ❛❧✳✱✷✵✵✶❀❉✉♣❡② ❛♥❞ ▼❡s❜❛❤✱✷✵✵✷✮ ❤❛✈❡ s✉❣❣❡st❡❞ t❤❛t ❥♦✐♥t ♠♦❞❡❧s ❝❛♥ ❜❡ ✉s❡❞ ✇❤❡♥ t❤❡ ❢♦❝✉s ✐s ♦♥ ❧♦♥❣✐t✉❞✐♥❛❧ ♠♦❞❡❧✐♥❣ ❛ss♦❝✐❛t❡❞ ✇✐t❤ ♣❛rt✐❝✐♣❛♥t ❞r♦♣♦✉t✳ ❍♦✇ ♦r ✐❢ ❥♦✐♥t ❛♥❞ t✇♦✲♣❛rt ♠♦❞❡❧s ❞✐✛❡r ❢r♦♠ ❛ st❛♥❞❛r❞ ♠✐①❡❞ ♠♦❞❡❧ ❛♣♣r♦❛❝❤ ✇✐❧❧ ❜❡ t❤❡ ❝♦♥❝❡♣t ❡①♣❧♦r❡❞ ✐♥ t❤✐s ❛♥❛❧②s✐s✳ ■✳✷ ❇❛❝❦❣r♦✉♥❞ ❚❤❡ ❈❖P❉●❡♥❡ st✉❞② ✐s ❛ ♠✉❧t✐❝❡♥t❡r ♣r♦❥❡❝t ❞❡✈❡❧♦♣❡❞ t♦ ✐❞❡♥t✐❢② ❣❡♥❡t✐❝ r✐s❦ ❢❛❝t♦rs ❛ss♦❝✐❛t❡❞ ✇✐t❤ t❤❡ ♣r♦❣r❡ss✐♦♥ ♦❢ ❈❤r♦♥✐❝ ❖❜str✉❝t✐✈❡ P✉❧♠♦♥❛r② ❉✐s❡❛s❡ ♦r ❈❖P❉✳ ❲❤✐❧❡ ✐t ✐s ✇❡❧❧ ❡st❛❜❧✐s❤❡❞ t❤❛t s♠♦❦✐♥❣ ✐s ❛ r✐s❦ ❢❛❝t♦r ❢♦r ♣✉❧♠♦♥❛r② ❞✐s❡❛s❡✱ ✐t ✐s ♥♦t ❦♥♦✇♥ ✇❤② s♦♠❡ s♠♦❦❡rs ❞❡✈❡❧♦♣ ❈❖P❉ ✇❤✐❧❡ ♦t❤❡rs ❞♦ ♥♦t✳ ❚❤❡ st✉❞② ❤♦♣❡s t♦ ♥♦t ♦♥❧② ❛❞❞r❡ss t❤✐s q✉❡st✐♦♥✱ ❜✉t t♦ ❛❧s♦ ✐♥❝r❡❛s❡ t❤❡ ❣❡♥❡r❛❧ ❦♥♦✇❧❡❞❣❡ ♦❢ ❤♦✇ t❤❡ ❞✐s❡❛s❡ ♣r♦❣r❡ss❡s ♦✈❡r t✐♠❡✳ ❚❤❡ st✉❞② ✐s ♦♥❣♦✐♥❣✱ ❜✉t ❛s ♦❢ ❏✉♥❡✱ ✷✵✵✶ ✇❤❡♥ t❤❡ ✐♥✐t✐❛❧ ❡♥r♦❧❧♠❡♥t ❣♦❛❧ ♦❢ ✶✵✱✵✵✵ s✉❜❥❡❝ts ✇❛s ❢✉❧✜❧❧❡❞✱ ❛❝t✐✈❡ r❡❝r✉✐t♠❡♥t ✇❛s ♥♦ ❧♦♥❣❡r t❛❦✐♥❣ ♣❧❛❝❡✳ ❆t t❤❡ st❛rt ♦❢ t❤❡ st✉❞②✱ ❛ ❤♦st ♦❢ ♠❡❞✐❝❛❧ ❛♥❞ ❞❡♠♦❣r❛♣❤✐❝ ✐♥❢♦r♠❛t✐♦♥ ✇❛s ❝♦❧❧❡❝t❡❞ ♦♥ ♣❛rt✐❝✐♣❛♥ts ❛♥❞ t❤✐s s❡r✐❡s ♦❢ t❡sts ✐s r❡♣❡❛t❡❞ ❛t t❤❡ ♥❡①t ❝❧✐♥✐❝❛❧ ✈✐s✐t ❛♣♣r♦①✐♠❛t❡❧② ✜✈❡ ②❡❛rs ❧❛t❡r✳ ❆❢t❡r ❡❛❝❤ ✈✐s✐t✱ s✉❜❥❡❝ts ❛r❡ ❣✐✈❡♥ ●❖▲❉ r❛t✐♥❣s ❜❛s❡❞ ♦♥ t❤❡ s❡✈❡r✐t② ♦❢ t❤❡✐r ❈❖P❉✳ ●❖▲❉ ✐s s❤♦rt ❢♦r t❤❡ ●❧♦❜❛❧ ✐♥✐t✐❛t✐✈❡ ❢♦r ❝❤r♦♥✐❝ ❖❜str✉❝t✐✈❡ ▲✉♥❣ ❉✐s❡❛s❡ ❛♥❞ ✇❛s ❞❡✈❡❧♦♣❡❞ ❢r♦♠ ❛ ❝♦❧❧❛❜♦r❛t✐♦♥ ❜❡t✇❡❡♥ t❤❡ ◆❛t✐♦♥❛❧ ■♥st✐t✉t❡s ♦❢ ❍❡❛❧t❤ ❛♥❞ t❤❡ ❲♦r❧❞ ❍❡❛❧t❤ ❖r❣❛♥✐③❛t✐♦♥ ✭❙❡♥✐♦r ❛♥❞ ❙✐❧✈❡r♠❛♥✱✷✵✵✼✮✳ ❚❤❡ ●❖▲❉ s②st❡♠ ❝❧❛ss✐✜❡s ♣❡♦♣❧❡ ❜❛s❡❞ ♦♥ t❤❡ r❡s✉❧ts ♦❢ ♣✉❧♠♦♥❛r② ❢✉♥❝t✐♦♥ t❡sts ❣✐✈❡♥ t♦ ♠❡❛s✉r❡ t❤❡✐r ❛✐r✢♦✇ ♦❜str✉❝t✐♦♥✳ ❲❤❡♥ ❜❧♦✇✐♥❣ ♦✉t ❢♦r❝❡❢✉❧❧②✱ ♣❡♦♣❧❡ ✇✐t❤ ♥♦r♠❛❧ ❧✉♥❣ ❢✉♥❝t✐♦♥ ❝❛♥ ❡①❤❛❧❡ ♠♦st ♦❢ t❤❡ ❛✐r ✐♥ t❤❡✐r ❧✉♥❣s ✐♥ ♦♥❡ ✷

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s❡❝♦♥❞✳ ❚❤✐s ♠❡❛s✉r❡♠❡♥t ✐s ❝❛❧❧❡❞ t❤❡ ❢♦r❝❡❞ ❡①♣✐r❛t♦r② ✈♦❧✉♠❡ ✐♥ ♦♥❡ s❡❝♦♥❞ ✭❋❊❱✶✮ ❛♥❞ ✐s ♠❡❛s✉r❡❞ ✐♥ ❧✐t❡rs✳ ❇❛s❡❞ ♦♥ t❤❡ ❞✐♠✐♥✐s❤✐♥❣ ❧❡✈❡❧s ♦❢ ❋❊❱✶ r❡❧❛t✐✈❡ t♦ ♥♦r♠❛❧ ❧✉♥❣ ❢✉♥❝t✐♦♥✱ ●❖▲❉ st❛❣❡ ❝❧❛ss✐✜❝❛t✐♦♥s r❛♥❣❡ ❢r♦♠ t❤❡ ♠✐❧❞ ❈❖P❉ ♦❢ ❙t❛❣❡ ✶ t♦ t❤❡ ✈❡r② s❡✈❡r❡ ❈❖P❉ ♦❢ ❙t❛❣❡ ✹✳ ■✳✸ ◗✉❡st✐♦♥ ♦❢ ■♥t❡r❡st ❲✐t❤ s✉❝❤ ❛ ❧❛r❣❡ ♥✉♠❜❡r ♦❢ ❡♥r♦❧❧❡❡s ✐♥ t❤❡ st✉❞②✱ ❛♥❞ ❜❡❝❛✉s❡ ❝❧✐♥✐❝❛❧ ✈✐s✐ts ❛r❡ s❡♣✲ ❛r❛t❡❞ ❜② ❛ ✜✈❡ ②❡❛r t✐♠❡ s♣❛♥✱ ❛ s✐❣♥✐✜❝❛♥t ♥✉♠❜❡r ♦❢ s✉❜❥❡❝ts ✇✐❧❧ ♥♦t r❡❛❝❤ t❤❡ s❡❝♦♥❞ ✈✐s✐t ♠✐❧❡st♦♥❡✳ ❍♦✇ t♦ ❛❝❝♦✉♥t ❢♦r ♠✐ss✐♥❣ ✈❛❧✉❡s ✇❤❡♥ ❡st✐♠❛t✐♥❣ ❋❊❱✶ ♣r♦❣r❡ss✐♦♥ ❜② ●❖▲❉ st❛❣❡ ✇❛s ❛ ♣♦✐♥t ♦❢ ❝♦♥s✐❞❡r❛t✐♦♥ ❢♦r ❛♥❛❧②s✐s✳ ❚♦ ♠♦❞❡❧ ❋❊❱✶ ♣r♦❣r❡ss✐♦♥ ❧♦♥❣✐✲ t✉❞✐♥❛❧❧②✱ ❡❛❝❤ ❋❊❱✶ r❡❛❞✐♥❣ ✇❛s ❝♦♥s✐❞❡r❡❞ ❛ s❡♣❛r❛t❡ ♦✉t❝♦♠❡ ❛♥❞ r❛♥❞♦♠ ❡✛❡❝ts ✇❡r❡ ✉s❡❞ t♦ ❛❝❝♦✉♥t ❢♦r t❤❡ r❡♣❡❛t❡❞ ♠❡❛s✉r❡s ✇✐t❤✐♥ s✉❜❥❡❝ts✳ ❙♣❡❝✐✜❝❛❧❧②✱ ❛ r❛♥❞♦♠ ✐♥t❡r✲ ❝❡♣t ❛❧❧♦✇❡❞ ❢♦r ✉♥♦❜s❡r✈❡❞ ❞✐✛❡r❡♥❝❡s ✐♥ st❛rt✐♥❣ ❋❊❱✶ ✈❛❧✉❡s ❜❡t✇❡❡♥ s✉❜❥❡❝ts ✇✐t❤ t❤❡ s❛♠❡ s❡t ♦❢ ❝♦✈❛r✐❛t❡s✱ ✇❤✐❧❡ ✐t ✇❛s ❤♦♣❡❞ ❛ r❛♥❞♦♠ s❧♦♣❡ ✇♦✉❧❞ ❝❛♣t✉r❡ t❤❡ ✈❛r✐❛❜✐❧✐t② ✐♥ s✉❜❥❡❝t s♣❡❝✐✜❝ ❋❊❱✶ tr❛❥❡❝t♦r✐❡s ♦✈❡r t✐♠❡✳ ■t ✇❛s t❤❡s❡ r❛♥❞♦♠ ❡✛❡❝ts ✇❤✐❝❤ ✇❡r❡ ♦❢ ✐♥t❡r❡st ✇❤❡♥ ❝♦♥s✐❞❡r✐♥❣ ❛ ♠✐①❡❞ ❞✐str✐❜✉t✐♦♥ ❛♥❛❧②s✐s✳ ■♥ ❜♦t❤ ❥♦✐♥t ❛♥❞ t✇♦✲♣❛rt ♠♦❞❡❧s✱ ♣❛rt✐❝✐♣❛♥t ❞r♦♣♦✉t ✐s ♠♦❞❡❧❡❞ ✐♥ ❛ s❡♣❛r❛t❡ ❝♦♠♣♦♥❡♥t ♦❢ t❤❡ ♠♦❞❡❧✳ ❚❤❡ r❛♥❞♦♠ ❡✛❡❝ts ❢r♦♠ t❤❡ s✉r✈✐✈❛❧ ❝♦♠♣♦♥❡♥t ❛r❡ t❤❡♥ s❤❛r❡❞ ✇✐t❤ t❤❡ r❛♥❞♦♠ ❡✛❡❝ts ❢r♦♠ t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❝♦♠♣♦♥❡♥t✳ ❚❤❡ ✐♠♣❛❝t ♦❢ t❤❡s❡ s❤❛r❡❞ r❛♥❞♦♠ ❡✛❡❝ts ♦♥ ❋❊❱✶ ♣r♦❣r❡ss✐♦♥ ✇❛s ✇❤❛t ✇❡ ❤♦♣❡❞ t♦ ❜❡tt❡r ✉♥❞❡rst❛♥❞ t❤r♦✉❣❤ t❤❡ ✐♥✈❡st✐❣❛t✐♦♥ ♦❢ t❤❡ t✇♦ ♠❡t❤♦❞s✳ ✸

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❈❍❆P❚❊❘ ■■ ❉❆❚❆ ■■✳✶ ●♦❧❞ ❙t❛❣❡ ●❖▲❉ st❛❣✐♥❣ ✐s ✉s❡❞ ❜② ❤❡❛❧t❤ ❡①♣❡rts t♦ ❤❡❧♣ ♣❡♦♣❧❡ ❜❡tt❡r ✉♥❞❡rst❛♥❞ t❤❡ ❞✐s❡❛s❡ ❛♥❞ t♦ ❛ss✐st ✐♥ ♠❛❦✐♥❣ tr❡❛t♠❡♥t r❡❝♦♠♠❡♥❞❛t✐♦♥s✳ ❙t❛❣❡ ■ ✐s ❝♦♥s✐❞❡r❡❞ ♠✐❧❞ ❈❖P❉✱ ❙t❛❣❡ ■■ ♠♦❞❡r❛t❡✱ ❙t❛❣❡ ■■■ s❡✈❡r❡✱ ❛♥❞ ❙t❛❣❡ ■❱ ✈❡r② s❡✈❡r❡ ❈❖P❉✳ ❚❤❡ ❈❖P❉●❡♥❡ st✉❞② ✉t✐❧✐③❡s ❛❞❞✐t✐♦♥❛❧ ❝❧❛ss✐✜❝❛t✐♦♥s ♦❢ ❙t❛❣❡ ✵ ❛♥❞ P❘■❙♠✳ ❚❤❡s❡ ❛r❡ ❣✐✈❡♥ t♦ ✐♥❞✐✈✐❞✉❛❧s ✇✐t❤ ✈❛r✐♦✉s r✐s❦ ❢❛❝t♦rs ❛ss♦❝✐❛t❡❞ ✇✐t❤ ❈❖P❉ ❛♥❞ ✐♥❞✐❝❛t❡ s✉❜❥❡❝ts ✇❤♦ ♠❛② ❜❡ ❛t r✐s❦ ❢♦r ❞❡✈❡❧♦♣✐♥❣ t❤❡ ❞✐s❡❛s❡✳ ❆t t❤❡ t✐♠❡ t❤❡ ❞❛t❛ s❡t ✇❛s ♣r❡♣❛r❡❞✱ ✷✱✵✵✵ ♣❛rt✐❝✐♣❛♥ts ❤❛❞ ❝♦♠♣❧❡t❡❞ ❜♦t❤ st✉❞② ✈✐s✐ts ❛♥❞ ✻✻✵ ♣❛rt✐❝✐♣❛♥ts ❤❛❞ ❞✐❡❞ s♦♠❡t✐♠❡ ❜❡t✇❡❡♥ t❤❡ ✜rst ❛♥❞ s❡❝♦♥❞ st✉❞② ✈✐s✐ts✳ ❋♦r t❤❡s❡ ✐♥❞✐✈✐❞✉❛❧s✱ t❤❡ ❞❛t❡ ♦❢ ❞❡❛t❤ ✇❛s r❡❝♦r❞❡❞✱ ❜✉t ♥♦t t❤❡ ❝❛✉s❡✳ P❛rt✐❝✐♣❛♥ts ✇❡r❡ ❝❧❛ss✐✜❡❞ ❛s ♠✐ss✐♥❣ ✐❢ ♠♦r❡ t❤❛♥ ✻ ②❡❛rs ❤❛❞ ❡❧❛♣s❡❞ s✐♥❝❡ t❤❡✐r ✜rst ✈✐s✐t ✭✻✽✹ s✉❜❥❡❝ts✮ ♦r ✐❢ ✇❤❡♥ ❝♦♥t❛❝t❡❞✱ t❤❡② ❞❡❝❧✐♥❡❞ ❢✉rt❤❡r ♣❛rt✐❝✐♣❛t✐♦♥ ✭✶✼✼ s✉❜❥❡❝ts✮✳ ❚❤✐s r❡s✉❧t❡❞ ✐♥ ❛ ❞❛t❛s❡t ♦❢ ✸✱✺✷✶ s✉❜❥❡❝ts s♣❧✐t ❜② ●❖▲❉ st❛❣❡ ❛s ✐❧❧✉str❛t❡❞ ✐♥ ❋✐❣✉r❡ ■■✳✶✳ ■♥ t❤❡ ❧❛t❡r st❛❣❡s ♦❢ t❤❡ ❞✐s❡❛s❡✱ st❛❣❡ ■■■ ❛♥❞ st❛❣❡ ■❱✱ t❤❡ t♦t❛❧ ♥✉♠❜❡r ♦❢ ❞❡❝❡❛s❡❞ ❛♥❞ ♠✐ss✐♥❣ ♣❛rt✐❝✐♣❛♥ts ✇❛s ❣r❡❛t❡r t❤❛♥ t❤❡ ♥✉♠❜❡r ♦❢ ♣❛rt✐❝✐♣❛♥ts ✇❤♦ ❝♦♠♣❧❡t❡ t❤❡ s❡❝♦♥❞ ❝❧✐♥✐❝❛❧ ✈✐s✐t✳ ❋♦r st❛❣❡s ■ ❛♥❞ ■■✱ ❜❡t✇❡❡♥ ✺✶✪ ❛♥❞ ✺✾✪ ♦❢ s✉❜❥❡❝ts ❝♦♠♣❧❡t❡❞ t❤❡ s❡❝♦♥❞ ✈✐s✐t✱ r❡s♣❡❝t✐✈❡❧②✳ ❋✐❣✉r❡ ■■✳✷ s❤♦✇s ❛ s✉r✈✐✈❛❧ ❝✉r✈❡ ❢r♦♠ ♣❛rt✐❝✐♣❛♥t ❡♥tr❛♥❝❡ ✐♥t♦ t❤❡ st✉❞② ✉♣ ✉♥t✐❧ t❤❡ s❡❝♦♥❞ st✉❞② ✈✐s✐t ❢♦r st❛❣❡s ■ − ■❱ ♦❢ t❤❡ ❞✐s❡❛s❡✳ ❆s ✇♦✉❧❞ ❜❡ ❡①♣❡❝t❡❞✱ ♠♦rt❛❧✐t② ✐♥❝r❡❛s❡❞ ✇✐t❤ st❛❣❡✳ ❙t❛❣❡s ■✱ ■■✱ ❛♥❞ ■■■ ❤❛❞ r❡❧❛t✐✈❡❧② ✢❛t ♠♦rt❛❧✐t② ❢♦r t❤❡ ✜rst ②❡❛r✳ ❆❢t❡r✇❛r❞✱ ♠♦rt❛❧✐t② ❢♦r st❛❣❡ ■■■ ✐♥❝r❡❛s❡❞ r❡❧❛t✐✈❡ t♦ t❤❡ ♦t❤❡r t✇♦ ❣r♦✉♣s ❛❢t❡r ♣❛rt✐❝✐♣❛♥ts ❤❛❞ ❜❡❡♥ ✐♥ t❤❡ st✉❞② ❢♦r ❛♣♣r♦①✐♠❛t❡❧② ✶✳✺ ②❡❛rs✳ ❚❤❡ ♠♦rt❛❧✐t② r❛t❡ ❢♦r st❛❣❡ ■■ ✐♥❝r❡❛s❡❞ r❡❧❛t✐✈❡❧② t♦ st❛❣❡ ■ ❛❢t❡r ❛♣♣r♦①✐♠❛t❡❧② ✷✳✷ ②❡❛rs✳ ❋♦r ❙t❛❣❡ ■❱✱ ❞❡❛t❤s ♦❝❝✉rr❡❞ st❡❛❞✐❧② t❤r♦✉❣❤♦✉t t❤❡ ❢♦❧❧♦✇ ✉♣ ♣❡r✐♦❞ ✇✐t❤ ♦♥❧② ✷✾✪ ♦❢ ♣❛rt✐❝✐♣❛♥ts s✉r✈✐✈✐♥❣ ✉♥t✐❧ t❤❡ s❡❝♦♥❞ ✈✐s✐t✳ ■■✳✷ ❆❞❞✐t✐♦♥❛❧ ❍❡❛❧t❤ ■♥❢♦r♠❛t✐♦♥ ❲❤✐❧❡ t❤❡ ♣r♦❣r❡ss✐♦♥ ♦❢ ❋❊❱✶ ✇✐t❤✐♥ ●❖▲❉ st❛❣❡ ✇❛s ❛♥ ✐♠♣♦rt❛♥t ✐♥❞✐❝❛t♦r ♦❢ ♣❛✲ t✐❡♥t ❤❡❛❧t❤✱ t❤❡ ❞❛t❛ s❡t ❝♦♥t❛✐♥❡❞ ♦t❤❡r ✈❛r✐❛❜❧❡s ✇❤✐❝❤ ✐♥❢♦r♠❡❞ ♦♥ ❞❡❛t❤ ❛♥❞ ❞✐s❡❛s❡ ✹

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❋✐❣✉r❡ ■■✳✶✿ ❙✉❜❥❡❝t st❛t✉s ❛❢t❡r ✜✈❡ ②❡❛rs ❜❛s❡❞ ♦♥ ❜❛s❡❧✐♥❡ ●❖▲❉ st❛❣❡✳ ♣r♦❣r❡ss✐♦♥✳ ❙t❛♥❞❛r❞ ✐♥❢♦r♠❛t✐♦♥ ❝♦❧❧❡❝t❡❞ ❛t ❡❛❝❤ st✉❞② ✈✐s✐t ✐♥❝❧✉❞❡❞ ❛❣❡✱ ❤❡✐❣❤t✱ ✇❡✐❣❤t✱ ❣❡♥❞❡r✱ ❛♥❞ ❡t❤♥✐❝✐t②✳ ❚❤❡ ♣r❡s❡♥❝❡ ❛♥❞ s❡✈❡r✐t② ♦❢ ❡♠♣❤②s❡♠❛✱ ❛s ✇❡❧❧ ❛s ✐❢ s✉❜❥❡❝ts ✇❡r❡ t❛❦✐♥❣ st❛♥❞❛r❞ ♠❡❞✐❝❛t✐♦♥s t♦ tr❡❛t ♣✉❧♠♦♥❛r② ❝♦♥❞✐t✐♦♥s s✉❝❤ ❛s ❜r♦♥❝❤✐t✐s✱ ❡♠♣❤②s❡♠❛ ❛♥❞ ❛st❤♠❛✱ ✇❛s ❛❧s♦ r❡❝♦r❞❡❞✳ ❊①t❡♥s✐✈❡ ✐♥❢♦r♠❛t✐♦♥ ♦♥ s♠♦❦✐♥❣ ❤❛❜✐ts ✇❛s ♦❜t❛✐♥❡❞✱ ❜✉t ❢♦r t❤❡ ♣✉r♣♦s❡ ♦❢ t❤✐s ❛♥❛❧②s✐s✱ s♠♦❦✐♥❣ st❛t✉s ✇❛s r❡❞✉❝❡❞ t♦ ❛ ❞✐❝❤♦t♦♠♦✉s ✈❛r✐❛❜❧❡ ❝♦♠✲ ♣❛r✐♥❣ ❢♦r♠❡r s♠♦❦❡rs t♦ ❝✉rr❡♥t ❛♥❞ ♠✐①❡❞ ✉s❡rs✳ ❇❡t✇❡❡♥ ❝❧✐♥✐❝❛❧ ✈✐s✐ts✱ ♣❛rt✐❝✐♣❛♥ts ✇❡r❡ ❝♦♥t❛❝t❡❞ ❜② ♣❤♦♥❡ ❡✈❡r② s✐① ♠♦♥t❤s ✇✐t❤ q✉❡st✐♦♥s ♦♥ ♦✈❡r❛❧❧ ♣✉❧♠♦♥❛r② ❤❡❛❧t❤✳ ◗✉❡s✲ t✐♦♥s ♦♥ t❤❡ ♦❝❝✉rr❡♥❝❡ ❛♥❞ s❡✈❡r✐t② ♦❢ s❡✈❡r❡ ❡①❛❝❡r❜❛t✐♦♥s ❞✉r✐♥❣ t❤❡ ♣r✐♦r s✐① ♠♦♥t❤s ✇❡r❡ ✐♥❝❧✉❞❡❞✱ ✇✐t❤ ♣♦s✐t✐✈❡ ❝♦✉♥ts ♦❢t❡♥ ✐♥❞✐❝❛t✐♥❣ ❛ ✇♦rs❡♥✐♥❣ ♦❢ ♣✉❧♠♦♥❛r② ❢✉♥❝t✐♦♥✐♥❣✳ ❋✐❣✉r❡ ■■✳✸ s❤♦✇s t❤❡ r❡❧❛t✐♦♥s❤✐♣ ❜❡t✇❡❡♥ ❡st✐♠❛t❡❞ ❋❊❱✶ ♣r♦❣r❡ss✐♦♥ ❜② ●❖▲❉ st❛❣❡ ❛♥❞ t❤❡ ♦❝❝✉rr❡♥❝❡ ♦❢ s❡✈❡r❡ ❡①❛❝❡r❜❛t✐♦♥s✳ ❋♦r ❛❧❧ st❛❣❡s ❡①❝❡♣t st❛❣❡ ■❱✱ ✐❢ ♣❛rt✐❝✐♣❛♥ts ❡①♣❡r✐❡♥❝❡❞ ❛ s❡✈❡r❡ ❡①❛❝❡r❜❛t✐♦♥ ❞✉r✐♥❣ t❤❡ ✜✈❡ ②❡❛r ❢♦❧❧♦✇ ✉♣✱ t❤❡② ❤❛❞✱ ♦♥ ❛✈❡r❛❣❡✱ ❛ ❜✐❣❣❡r ❞❡❝r❡❛s❡ ✐♥ ❋❊❱✶ ❜❡t✇❡❡♥ ✈✐s✐t ✶ ❛♥❞ ✈✐s✐t ✷✳ ❋♦r st❛❣❡ ■❱✱ t❤❡ ❝❤❛♥❣❡ ✐♥ ❋❊❱✶ ❢♦r ❛❧❧ ♣❛rt✐❝✐♣❛♥ts ❜❡t✇❡❡♥ ✈✐s✐ts ✇❛s r❡❧❛t✐✈❡❧② ✢❛t✳ ✺

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❋✐❣✉r❡ ■■✳✷✿ ❑❛♣❧❛♥✲▼❡✐❡r ❙✉r✈✐✈❛❧ ❈✉r✈❡ ❢♦r ●❖▲❉ ❙t❛❣❡ ■ ✲ ■❱✳ ❉❛②s ❛r❡ ♠❡❛s✉r❡❞ ❢r♦♠ ♣❛rt✐❝✐♣❛♥t ❡♥tr② ✐♥t♦ t❤❡ st✉❞②✳ ❋✐❣✉r❡ ■■✳✸✿ ❋❊❱✶ ❛t ❡❛❝❤ ✈✐s✐t ❜② ●❖▲❉ st❛❣❡ ❛♥❞ s❡✈❡r❡ ❡①❛❝❡r❜❛t✐♦♥s st❛t✉s✳ ❚❤❡ ❛✈❡r❛❣❡ ❋❊❱✶ ❢♦r ♣r❡✲st❛❣❡ ❈❖P❉ ♣❛rt✐❝✐♣❛♥ts ✐s r❡♣r❡s❡♥t❡❞ ♦♥ t❤❡ ❧❡❢t s❡❝t✐♦♥ ♦❢ t❤❡ ❣r❛♣❤✱ ✇✐t❤ ❙t❛❣❡s ✶ ✲ ✹ ♦♥ t❤❡ r✐❣❤t✳ ❚❤❡ s♦❧✐❞ ❧✐♥❡ r❡♣r❡s❡♥ts t❤❡ ❛✈❡r❛❣❡ ❝❤❛♥❣❡ ✐♥ ❋❊❱✶ ❢r♦♠ ✈✐s✐t ✶ t♦ ✈✐s✐t ✷ ❢♦r ♣❛rt✐❝✐♣❛♥ts ✇❤♦ ❞✐❞ ♥♦t ❤❛✈❡ ❛♥② s❡✈❡r❡ ❡①❛❝❡r❜❛t✐♦♥s ❜❡t✇❡❡♥ ✈✐s✐ts✳ ❚❤❡ ❞❛s❤❡❞ ❧✐♥❡ r❡♣r❡s❡♥ts t❤❡ ❝❤❛♥❣❡ ❢♦r ✐♥❞✐✈✐❞✉❛❧s ✇❤♦ ❡①♣❡r✐❡♥❝❡❞ ❛t ❧❡❛st ♦♥❡ ❡①❛❝❡r❜❛t✐♦♥ ❞✉r✐♥❣ ❢♦❧❧♦✇ ✉♣ ✻

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❈❍❆P❚❊❘ ■■■ ▲❖◆●■❚❯❉■◆❆▲ ❈❖◆❙■❉❊❘❆❚■❖◆❙ ■■■✳✶ ❙♦❢t✇❛r❡ ❈❤♦✐❝❡ ❆s t❤✐s ❛♥❛❧②s✐s ✉t✐❧✐③❡s ♠❡t❤♦❞s ❛♥❞ ❝♦❞❡ ❞❡✈❡❧♦♣❡❞ ❜② ♦t❤❡r ❛✉t❤♦rs ✐♥ ❙❆❙✱ ❙❆❙ ✈❡rs✐♦♥ ✾✳✹ ✇❛s ✉s❡❞ t❤r♦✉❣❤♦✉t t❤❡ ♣r♦❥❡❝t✳ ■■■✳✷ ❉❡✈❡❧♦♣♠❡♥t ♦❢ ❛ ❘❛♥❞♦♠ ❙❧♦♣❡ ❆ ❝♦♥s✐❞❡r❛t✐♦♥ ✇❤❡♥ ♠♦❞❡❧✐♥❣ ❈❖P❉●❡♥❡ ❞❛t❛ ❧♦♥❣✐t✉❞✐♥❛❧❧② ✇❛s t❤❡r❡ ✇❡r❡ ♦♥❧② t✇♦ ❋❊❱✶ r❡❛❞✐♥❣s ❢♦r ❛❝t✐✈❡ ♣❛rt✐❝✐♣❛♥ts ❛♥❞ ♦♥❧② t❤❡ ✐♥❢♦r♠❛t✐♦♥ ❢r♦♠ t❤❡ ✐♥✐t✐❛❧ ✈✐s✐t ❢♦r ♣❛rt✐❝✐♣❛♥ts ✇❤♦ ❞✐❡❞✳ ■❢ ❞❡❛t❤s ✇❡r❡ t♦ ✐♥❢♦r♠ ♦♥ t❤❡ s✉❜❥❡❝t s♣❡❝✐✜❝ ❋❊❱✶ tr❛❥❡❝t♦r✐❡s ♦✈❡r t✐♠❡✱ ✐t s❡❡♠❡❞ r❡❛s♦♥❛❜❧❡ t❤❛t ❛❞❞✐t✐♦♥❛❧ ❧♦♥❣✐t✉❞✐♥❛❧ ❞❛t❛ ✇❛s ♥❡❡❞❡❞✳ ❋r♦♠ t❤❡ s❡♠✐✲❛♥♥✉❛❧ ♣❤♦♥❡ s✉r✈❡②s✱ t❤❡ r❡❧❛t✐♦♥s❤✐♣ ❜❡t✇❡❡♥ s❡✈❡r❡ ❡①❛❝❡r❜❛t✐♦♥s ❛♥❞ ❋❊❱✶ ✇❛s ❡①❛♠✐♥❡❞ ✇✐t❤ t❤❡ ❣♦❛❧ ♦❢ ❞❡✈❡❧♦♣✐♥❣ ❛ s❤❛r❡❞ r❛♥❞♦♠ s❧♦♣❡ ❜❡t✇❡❡♥ ❝♦♠♣♦♥❡♥ts ♦❢ ❛ ❝♦♠♣♦s✐t❡ ♠♦❞❡❧✳ ❇❡❢♦r❡ ❝♦♥s✐❞❡r✐♥❣ ❞❡❛t❤s✱ ✐♥✐t✐❛❧ ❛♥❛❧②s✐s ❧♦♦❦❡❞ ❛t ❛❞❞✐♥❣ s❡✈❡r❡ ❡①❛❝❡r❜❛t✐♦♥s ❝♦✉♥ts ♦✈❡r t✐♠❡ t♦ ❛ ❧♦♥❣✐t✉❞✐♥❛❧ ♠♦❞❡❧ ✇✐t❤ ❋❊❱✶ ❛s t❤❡ ♣r✐♠❛r② ♦✉t❝♦♠❡ ❢♦r s✉❜❥❡❝ts ✇✐t❤ ❝♦♠♣❧❡t❡ ❋❊❱✶ r❡❛❞✐♥❣s✳ ❯s✐♥❣ ❛ ❣❡♥❡r❛❧✐③❡❞ ❧✐♥❡❛r ♠♦❞❡❧ ✭P❘❖❈ ●▲■▼▼■❳ ✐♥ ❙❆❙✮✱ t❤❡ ♦❜❥❡❝t✐✈❡ ✇❛s t♦ ♦❜t❛✐♥ r❡❛s♦♥❛❜❧❡ ❡st✐♠❛t❡s ❢♦r ❜♦t❤ t❤❡ ❜❡t❛ ♣❛r❛♠❡t❡rs ❛♥❞ r❛♥❞♦♠ ❡✛❡❝ts ✇❤✐❝❤ ❝♦✉❧❞ t❤❡♥ ❜❡ ✉s❡❞ ❛s st❛rt✐♥❣ ♣♦✐♥ts ✐♥ ❛ ❥♦✐♥t ♠♦❞❡❧ ❛♣♣r♦❛❝❤✳ ❍♦✇❡✈❡r✱ ❝♦♥✈❡r❣❡♥❝❡ ✐ss✉❡s ❛r♦s❡ ✇❤❡♥❡✈❡r ❛ r❛♥❞♦♠ s❧♦♣❡ ✇❛s ❛❞❞❡❞ t♦ t❤❡ ♠♦❞❡❧✱ ❛♥❞ r❡s✉❧ts ❢♦r t❤❡ r❛♥❞♦♠ ✐♥t❡r❝❡♣t ✇❡r❡ ✐♥❝♦♥s✐st❡♥t✳ ❚♦ ❜❡tt❡r ✉♥❞❡rst❛♥❞ ❤♦✇ s❡✈❡r❡ ❡①❛❝❡r❜❛t✐♦♥s ♠✐❣❤t ❛✛❡❝t ❋❊❱✶ tr❛❥❡❝t♦r✐❡s✱ ❛ ♠♦❞❡❧ ✇✐t❤ ❡①❛❝❡r❜❛t✐♦♥s ❛s t❤❡ ♦✉t❝♦♠❡ ♦❢ ✐♥t❡r❡st ✇✐t❤ t✐♠❡ ❛♥❞ st❛❣❡ ❛s ♣♦t❡♥t✐❛❧ ❝♦✈❛r✐❛t❡s ✇❛s t❤❡♥ ❝♦♥s✐❞❡r❡❞✳ ❇♦t❤ ❛ P♦✐ss♦♥ ❛♥❞ ❛ ◆❡❣❛t✐✈❡ ❇✐♥♦♠✐❛❧ ❞✐str✐❜✉t✐♦♥ ✇❡r❡ ❝♦♥s✐❞❡r❡❞ ❛♥❞ ✈❛r✐♦✉s ❝♦✈❛r✐❛t❡s ✇❡r❡ ❛❞❞❡❞ ✐♥ ❛♥ ❛tt❡♠♣t t♦ ✐♥❝❧✉❞❡ r❛♥❞♦♠ ❡✛❡❝ts ✐♥ t❤❡ ♠♦❞❡❧✳ ◆♦ ❝❧❡❛r ♣❛tt❡r♥ t♦ ❡①❛❝❡r❜❛t✐♦♥s ♦✈❡r t✐♠❡ ❡♠❡r❣❡❞ ❛♥❞ ❢♦❝✉s s❤✐❢t❡❞ t♦ ❛ ♠♦r❡ ✐♥✲❞❡♣t❤ ❧♦♦❦ ❛t ❝♦✉♥t ❞✐str✐❜✉t✐♦♥s✳ ✼

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■■■✳✸ ❉❛t❛ ✇✐t❤ ❊①❝❡ss ❩❡r♦s ❚❤❡ ♠❛❥♦r✐t② ♦❢ s✉❜❥❡❝ts ❞✐❞ ♥♦t ❡①♣❡r✐❡♥❝❡ ❛ s❡✈❡r❡ ❡♣✐s♦❞❡ ❞✉r✐♥❣ t❤❡ ♣❡r✐♦❞ ✐♥ q✉❡s✲ t✐♦♥✱ ✇❤✐❝❤ r❡s✉❧t❡❞ ✐♥ ❝♦✉♥t ❞❛t❛ ✇✐t❤ ❛♥ ❡①❝❡ss ♦❢ ③❡r♦s✳ ❆ ❜❛s✐❝ t❡♥❡t ♦❢ ❛ P♦✐ss♦♥ ❞✐str✐❜✉t✐♦♥ ✐s t❤❛t t❤❡ ❡①♣❡❝t❡❞ ♠❡❛♥ ✐s ❡q✉❛❧ t♦ t❤❡ ❡①♣❡❝t❡❞ ✈❛r✐❛♥❝❡✳ ❲✐t❤ ❛♥ ♦✈❡r❛❜✉♥✲ ❞❛♥❝❡ ♦❢ ③❡r♦s✱ t❤✐s ❛ss✉♠♣t✐♦♥ ✐s ✈✐♦❧❛t❡❞ ❜❡❝❛✉s❡ t❤❡ ✈❛r✐❛♥❝❡ ✐s ❣r❡❛t❡r t❤❛♥ t❤❡ ♠❡❛♥✳ ❈♦♠♠♦♥ ❞✐str✐❜✉t✐♦♥s ❛♥❞ ♠♦❞❡❧s ✉s❡❞ t♦ ❛❞❞r❡ss t❤✐s ♦✈❡r❞✐s♣❡rs✐♦♥ ❛r❡ ③❡r♦ ✐♥✢❛t❡❞ P♦✐s✲ s♦♥ ✭❩■P✮✱ ③❡r♦ ✐♥✢❛t❡❞ ♥❡❣❛t✐✈❡ ❜✐♥♦♠✐❛❧ ✭❩■◆❇✮✱ ❤✉r❞❧❡ P♦✐ss♦♥ ✭❍P✮ ❛♥❞ ❤✉r❞❧❡ ♥❡❣❛t✐✈❡ ❜✐♥♦♠✐❛❧ ✭❍◆❇✮ ♠♦❞❡❧s ✭❱♦r♦♥❝❛ ❡t ❛❧✳✱✷✵✶✹✮✳ ❆♥ ✐ss✉❡ ✇✐t❤ ✜tt✐♥❣ t❤❡s❡ t②♣❡s ♦❢ ♠✐①t✉r❡ ♠♦❞❡❧s ✐s t❤❛t ❣♦♦❞ ✐♥✐t✐❛❧ ❡st✐♠❛t❡s ❢♦r t❤❡ ♣❛r❛♠❡t❡rs ❛r❡ ♦❢t❡♥ ♥❡❡❞❡❞ ✐♥ ♦r❞❡r ❢♦r t❤❡ ♠♦❞❡❧ t♦ ❝♦♥✈❡r❣❡✳ ■♥ t❤❡✐r ♣❛♣❡r ❆♥❛❧②s✐s ♦❢ ③❡r♦ ✐♥✢❛t❡❞ ❧♦♥❣✐t✉❞✐♥❛❧ ❞❛t❛ ✉s✐♥❣ Pr♦❝ ◆▲▼■❳❊❉✱❱♦r♦♥❝❛ ❡t ❛❧✳✭✷✵✶✹✮ ❞❡✈❡❧♦♣❡❞ ❛ ❙❆❙ ♠❛❝r♦ ❞❡s✐❣♥❡❞ t♦ ❛ss✐st ✐♥ ♠♦❞❡❧ ✜tt✐♥❣ ❢♦r ③❡r♦ ✐♥✢❛t❡❞ ❛♥❞ ❝♦rr❡❧❛t❡❞ ❝♦✉♥t ❞❛t❛✳ ❯s✐♥❣ ♠♦❞✐✜❡❞ ❝♦❞❡ ❢r♦♠ t❤❡ ♣❛♣❡r✱ ♥✉♠❡r♦✉s ❛tt❡♠♣ts ❛t ♠♦❞❡❧✐♥❣ ❡①❛❝❡r❜❛t✐♦♥ ❝♦✉♥ts ♦✈❡r t✐♠❡ ✇❡r❡ ♠❛❞❡ ✉s✐♥❣ t❤❡ ❢♦✉r ❞✐str✐❜✉t✐♦♥s ❝♦❞❡❞ ✐♥ t❤❡ ♠❛❝r♦✳ ◆♦♥❡ ♦❢ t❤❡♠ ♣r♦✈✐❞❡❞ ❝♦♥s✐st❡♥t r❡s✉❧ts✳ ❚❤❡ ♠♦st ❝♦♠♠♦♥ ♦✉t❝♦♠❡ ✇❛s ♥♦♥✲❝♦♥✈❡r❣❡♥❝❡✱ ❛❧t❤♦✉❣❤ ❧✐♠✐t❡❞ ❝♦♥✈❡r❣❡♥❝❡ ✇❛s ♦❜t❛✐♥❡❞ ✇✐t❤ ❛ r❛♥❞♦♠ ✐♥t❡r❝❡♣t ❜✉t ♥♦t ❛ r❛♥❞♦♠ s❧♦♣❡✳ ❆s ♥♦ ❞✐s❝❡r♥✐❜❧❡ ❞✐✛❡r❡♥❝❡s ✐♥ ❡①❛❝❡r❜❛t✐♦♥ tr❛❥❡❝t♦r✐❡s ❜② s✉❜❥❡❝t ✇❛s ❡✈✐❞❡♥t✱ ✐♥❝❧✉❞✐♥❣ t❤❡ ❛❞❞✐t✐♦♥❛❧ ✐♥❢♦r♠❛t✐♦♥ ❝♦❧❧❡❝t❡❞ ❜❡t✇❡❡♥ ❝❧✐♥✐❝❛❧ st✉❞② ✈✐s✐ts ✇❛s ♥♦t ❝♦♥s✐❞❡r❡❞ ✐♥ ❢✉t✉r❡ ❛♥❛❧②s✐s✳ ✽

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❈❍❆P❚❊❘ ■❱ ❏❖■◆❚ ▼❖❉❊▲ ■❱✳✶ ❙❤❛r❡❞ ❘❛♥❞♦♠ ■♥t❡r❝❡♣t ❆ ❥♦✐♥t ♠♦❞❡❧ ❛♣♣r♦❛❝❤✱ ❛s ♣r♦♣♦s❡❞ ❜② ✈❛r✐♦✉s ❛✉t❤♦rs ✭▲❡✐✱ ✷✵✶✸❀ ❉✉♣❡② ❛♥❞ ▼❡s✲ ❜❛❤✱✷✵✵✷✮ ✇❛s t❤❡ ❜❛s✐s ❢♦r ❛♥ ❛♥❛❧②s✐s ❧♦♦❦✐♥❣ ❛t s✉❜❥❡❝ts ✇❤♦ ❤❛✈❡ ❜♦t❤ ❋❊❱✶ r❡❛❞✐♥❣s ✭❝♦♠♣❧❡t❡rs✮ ❛♥❞ t❤♦s❡ ✇❤♦ ❞✐❡❞ ❛❢t❡r t❤❡ ✜rst st✉❞② ✈✐s✐t✳ ❚❤❡ ❥♦✐♥t ♠♦❞❡❧ ❝♦♥s✐sts ♦❢ ❛ ❧♦♥✲ ❣✐t✉❞✐♥❛❧ ❝♦♠♣♦♥❡♥t ♦❢ ❋❊❱✶ ♣r♦❣r❡ss✐♦♥ ❛♥❞ ❛ s✉r✈✐✈❛❧ ❝♦♠♣♦♥❡♥t ✇✐t❤ t✐♠❡ t♦ ❡✈❡♥t✳ ❆ r❛♥❞♦♠ ✐♥t❡r❝❡♣t ✐s s❤❛r❡❞ ❜❡t✇❡❡♥ t❤❡ t✇♦ ❝♦♠♣♦♥❡♥ts ❛♥❞ ❜② s♦❧✈✐♥❣ ❢♦r t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❛♥❞ s✉r✈✐✈❛❧ ♣r♦❝❡ss❡s s✐♠✉❧t❛♥❡♦✉s❧②✱ t❤❡ ❥♦✐♥t ♠♦❞❡❧ ❛tt❡♠♣ts t♦ ❛❝❝♦✉♥t ❢♦r ❡st✐♠❛t✐♦♥ ❜✐❛s ✐♥ ❋❊❱✶ ✇❤✐❝❤ ♠✐❣❤t r❡s✉❧t ❢r♦♠ ✐❣♥♦r✐♥❣ t✐♠❡ t♦ ❞❡❛t❤✳ ❲❤✐❧❡ ❛ s✉r✈✐✈❛❧ ♠♦❞❡❧ ❛❝❝♦✉♥ts ❢♦r ❞r♦♣♦✉ts ❛s ❛♥ ✐♥❞❡♣❡♥❞❡♥t ❝❡♥s♦r✐♥❣ ❡✈❡♥t✱ t❤❡ ✐♥✐t✐❛❧ ❛♥❛❧②s✐s ❢♦❝✉s❡❞ ♦♥ ♦♥❧② ❝♦♠♣❧❡t❡rs ❛♥❞ s✉❜❥❡❝ts ✇❤♦ ❞✐❡❞ ❞✉r✐♥❣ t❤❡ ✜rst ✜✈❡ ②❡❛rs ♦❢ t❤❡ st✉❞②✳ ◆♦t❛t✐♦♥ ❢♦r t❤✐s ❥♦✐♥t ♠♦❞❡❧ ❝❛♥ ❜❡ ❡①♣r❡ss❡❞ ❛s✿ Yij ❂ ❚❤❡ ❋❊❱✶ ♦❢ s✉❜❥❡❝t i ❛t t✐♠❡ j ✇❤❡r❡ j = 1, 2 Ti ❂ t✐♠❡ t♦ ❞❡❛t❤ Ci ❂ ✐♥❞❡♣❡♥❞❡♥t ❝❡♥s♦r✐♥❣ ❡✈❡♥t✱ ✭❡✳❣✳✱ s❡❝♦♥❞ ✈✐s✐t✮ Xi ❂ ♠✐♥✭Ci✱Ti✮✿ t❤❡ ♦❜s❡r✈❡❞ ❢♦❧❧♦✇✲✉♣ t✐♠❡ ∆i ❂ ■✭Ti,≤ Ci✮✿ t❤❡ ❡✈❡♥t ✐♥❞✐❝❛t♦r hi(t)✿ ❤❛③❛r❞ ♦❢ ❞❡❛t❤ ❛t t✐♠❡ t ❲✐t❤ ❛ s❤❛r❡❞ r❛♥❞♦♠ ✐♥t❡r❝❡♣t✱ t❤❡ ❣❡♥❡r❛❧ ❢♦r♠s ❢♦r t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❛♥❞ s✉r✈✐✈❛❧ ❝♦♠♣♦♥❡♥ts ❛r❡✿ Yij = Zijβ+ ai+ eij. ✭■❱✳✶✮ hi(t) = h0(t)exp(Wiα+ γai). ✭■❱✳✷✮ ❋♦r t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ♠♦❞❡❧ ✭❡q✉❛t✐♦♥ ✹✳✶✮✱ Zij ✐s t❤❡ ❝♦✈❛r✐❛t❡ ✈❡❝t♦r ❢♦r s✉❜❥❡❝t i ❛t t✐♠❡ j✱ β ✐s ❛ ♣❛r❛♠❡t❡r ✈❡❝t♦r✱ ai ✐s ❛ s✉❜❥❡❝t s♣❡❝✐✜❝ r❛♥❞♦♠ ✐♥t❡r❝❡♣t t❡r♠ ✇❤❡r❡ ai ∼ i.i.d ◆✭✵✱ σ21✮ ❛♥❞ eij ✐s t❤❡ ❡rr♦r t❡r♠ ✇❤❡r❡ eij ∼ i.i.d ◆✭✵✱ σ 2 e✮✳ ❋♦r t❤❡ s✉r✈✐✈❛❧ ♠♦❞❡❧ ✾

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✭❡q✉❛t✐♦♥ ■❱✳✷✮✱ h0 r❡♣r❡s❡♥ts t❤❡ ❜❛s❡❧✐♥❡ ❤❛③❛r❞ ❢✉♥❝t✐♦♥✱ Wi ✐s t❤❡ ❝♦✈❛r✐❛t❡ ✈❡❝t♦r ❢♦r s✉❜❥❡❝t i ❛t ❜❛s❡❧✐♥❡✱ ❛♥❞ ai ✐s t❤❡ s❤❛r❡❞ r❛♥❞♦♠ ✐♥t❡r❝❡♣t t❡r♠ ❧✐♥❦✐♥❣ t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❛♥❞ s✉r✈✐✈❛❧ ♣r♦❝❡ss❡s✳ ❆s t❤❡ ❧✐♥❡❛r ♣r❡❞✐❝t♦rs ♦❢ t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❛♥❞ s✉r✈✐✈❛❧ ♠♦❞❡❧s ❤❛✈❡ ❞✐✛❡r❡♥t ❢♦r♠s ❛♥❞ t❤❡ ♦✉t❝♦♠❡s ❛r❡ ♦♥ ❞✐✛❡r❡♥t s❝❛❧❡s✱ ❛♥ ❛❞❞✐t✐♦♥❛❧ ♣❛r❛♠❡t❡r γ ✐s r❡q✉✐r❡❞ t♦ s❡r✈❡ ❛s ❛ ❧✐♥❦ ❜❡t✇❡❡♥ t❤❡ t✇♦✳ ❍❡r❡ ❣❛♠♠❛ r❡♣r❡s❡♥ts t❤❡ str❡♥❣t❤ ❛♥❞ ❞✐r❡❝t✐♦♥ ♦❢ t❤❡ ❛ss♦❝✐❛t✐♦♥ ❜❡t✇❡❡♥ t❤❡ t✇♦ ♣r♦❝❡ss❡s✳ ❙♣❡❝✐✜❝❛❧❧②✿ γ <✵✿ ❛ ❤✐❣❤❡r ❋❊❱✶ r❡❛❞✐♥❣ ✐s ❛ss♦❝✐❛t❡❞ ✇✐t❤ ❛ ❧♦✇❡r ❞❡❛t❤ r❛t❡✳ γ >✵✿ ❛ ❤✐❣❤❡r ❋❊❱✶ r❡❛❞✐♥❣ ✐s ❛ss♦❝✐❛t❡❞ ✇✐t❤ ❛ ❤✐❣❤❡r ❞❡❛t❤ r❛t❡✳ γ =✵✿ ♥♦ ❛ss♦❝✐❛t✐♦♥ ❜❡t✇❡❡♥ ❋❊❱✶ ❧❡✈❡❧s ❛♥❞ ❞❡❛t❤✳ ❯t✐❧✐③✐♥❣ t❤❡ ❙❆❙ ❝♦❞❡ ❞❡✈❡❧♦♣❡❞ ❜② ▲❡✐ ✭✷✵✶✸✮ t❤❡ ◆▲▼■❳❊❉ ♣r♦❝❡❞✉r❡ ✇❛s ✉s❡❞ t♦ ❝♦❞❡ t❤❡ ❥♦✐♥t ❞✐str✐❜✉t✐♦♥✳ ❆s ❝♦♥✈❡r❣❡♥❝❡ ✇✐t❤ ❛ ❥♦✐♥t ❧✐❦❡❧✐❤♦♦❞ ✐s ❞✐✣❝✉❧t ✇✐t❤♦✉t r❡❛s♦♥❛❜❧❡ st❛rt✐♥❣ ✈❛❧✉❡s ❢♦r t❤❡ ♣❛r❛♠❡t❡rs✱ ✐♥✐t✐❛❧ ❡st✐♠❛t❡s ❢♦r t❤❡ ❝♦✈❛r✐❛t❡s✱ ❛s ✇❡❧❧ ❛s st❛rt✐♥❣ ✈❛❧✉❡s ❢♦r t❤❡ r❛♥❞♦♠ ✐♥t❡r❝❡♣t ❛♥❞ ❡rr♦r t❡r♠✱ ✇❡r❡ ✜rst ❞❡✈❡❧♦♣❡❞ ✐♥ t❤❡ ▼■❳❊❉ ❛♥❞ ▲■❋❊❘❊● ♣r♦❝❡❞✉r❡s✳ ❚❤❡ ❜❛s✐❝ ❝♦✈❛r✐❛t❡s ❢♦r t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ♣r♦❣r❡ss✐♦♥ ♦❢ ❋❊❱✶ ✐♥❝❧✉❞❡❞ ●❖▲❉ st❛❣❡✱ t✐♠❡✱ ❛♥❞ ❛ st❛❣❡✯t✐♠❡ ✐♥t❡r❛❝t✐♦♥ t❡r♠✳ ❚✐♠❡ ✇❛s tr❡❛t❡❞ ❛s ❛ ❝♦♥t✐♥✉♦✉s ✈❛r✐❛❜❧❡ ✇✐t❤ ❛❝t✉❛❧ ❞❛t❡s ❢♦r ❞❡❛t❤ ❛♥❞ st✉❞② ✈✐s✐ts✳ ❋♦r t❤❡ s✉r✈✐✈❛❧ ❝♦♠♣♦♥❡♥t✱ t❤❡ ▲■❋❊❘❊● ♣r♦❝❡❞✉r❡ ♠♦❞❡❧❡❞ t❤❡ t✐♠❡✲t♦✲❡✈❡♥t ✭❞❡❛t❤✮ ✇✐t❤ ●❖▲❉ st❛❣❡ ❛s t❤❡ ♦♥❧② ❝♦✈❛r✐❛t❡s✳ ❋♦r t❤❡ ❣❛♠♠❛ ♣❛r❛♠❡t❡r✱ ❛♥ ❛rr❛② ♦❢ ✐♥✐t✐❛❧ st❛rt✐♥❣ ✈❛❧✉❡s ✇❛s ❝♦♥s✐❞❡r❡❞✳ ❇❡❣✐♥♥✐♥❣ ✇✐t❤ ✐♥✐t✐❛❧ ❣❛♠♠❛ ✈❛❧✉❡s ♦❢ ④✲✶✱ ✲✵✳✺✱ ✲✵✳✷✱ ✵✱ ✵✳✷✱ ✵✳✺✱ ✶⑥✱ t❤❡ ❥♦✐♥t ♠♦❞❡❧ ❝♦♥✈❡r❣❡❞ ✉♥❞❡r ❛❧❧ s❝❡♥❛r✐♦s ❛♥❞ r❡s✉❧t❡❞ ✐♥ ✜♥❛❧ ❣❛♠♠❛ ✈❛❧✉❡s t❤❛t ✇❡r❡ ♥❡❣❛t✐✈❡ ❛♥❞ r❛♥❣❡❞ ✐♥ ♠❛❣♥✐t✉❞❡ ❢r♦♠ ✭✲✵✳✹✻✱ ✲✵✳✶✺✮✳ ❆ ♠♦r❡ ♥❛rr♦✇ s❡❣♠❡♥t ♦❢ st❛rt✐♥❣ ❣❛♠♠❛ ✈❛❧✉❡s ✭❜❡t✇❡❡♥ ✲✵✳✺✱ ✵✮ ♣r♦❞✉❝❡❞ t❤❡ r❡s✉❧ts ❧✐st❡❞ ✐♥ ❚❛❜❧❡ ■❱✳✶✳ ❚❤❡ ♠♦❞❡❧ ❝♦♥✈❡r❣❡❞ ✇✐t❤ ❝♦♥s✐st❡♥t ✜♥❛❧ ❣❛♠♠❛ r❡s✉❧ts ✇❤❡♥ st❛rt✐♥❣ ❣❛♠♠❛ ✈❛❧✉❡s ✇❡r❡ ❜❡t✇❡❡♥ ✭✲✵✳✷✱ ✵✮✳ ❚❤❡ ♥❡❣❛t✐✈❡ ❣❛♠♠❛ ♣❛r❛♠❡t❡rs ✐♥❞✐❝❛t❡❞ ✐♥❞✐✈✐❞✉❛❧s ✇✐t❤ ❤✐❣❤❡r ❋❊❱✶ r❡❛❞✐♥❣s ❛t ❜❛s❡❧✐♥❡ ✇❡r❡ ❧❡ss ❧✐❦❡❧② t♦ ❞✐❡ ❜❡❢♦r❡ t❤❡ s❡❝♦♥❞ st✉❞② ✈✐s✐t✳ ✶✵

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❚❛❜❧❡ ■❱✳✶✿ ●❛♠♠❛ ❝♦♥✈❡r❣❡♥❝❡ ♦❢ t❤❡ ❥♦✐♥t ♠♦❞❡❧ ❢♦r ❧♦♥❣✐t✉❞✐♥❛❧ ❋❊❱✶ ❛♥❞ s✉r✈✐✈❛❧ t✐♠❡ ❢♦r s❡✈❡r❛❧ st❛rt✐♥❣ ✈❛❧✉❡s ♦❢ ❣❛♠♠❛✳ ❚❤❡ ♠♦❞❡❧ ❞♦❡s ♥♦t ❝♦♥✈❡r❣❡ ✇✐t❤ ❛ st❛rt✐♥❣ ✈❛❧✉❡ ♦❢ ✲✵✳✹✳ ❙t❛rt✐♥❣ ❊♥❞✐♥❣ ❙t❛♥❞❛r❞ ●❛♠♠❛ ●❛♠♠❛ ❊rr♦r ♣✲✈❛❧✉❡ ✲✵✳✺ ✲✵✳✶✹✽✽ ✵✳✶✵✻✷ ✵✳✶✻✶✵ ✲✵✳✹ ✯✯✯ ✯✯✯ ✯✯✯ ✲✵✳✸ ✲✵✳✶✻✸✼ ✵✳✶✵✻✷ ✵✳✶✷✸✸ ✲✵✳✷ ✲✵✳✷✷✸✻ ✵✳✶✵✼✸ ✵✳✵✸✼✷ ✲✵✳✶ ✲✵✳✷✹✼✼ ✵✳✶✵✼✻ ✵✳✵✷✶✹ ✵✳✵ ✲✵✳✷✺✽✹ ✵✳✶✵✽✵ ✵✳✵✶✻✽ ■❱✳✷ ❆❧t❡r♥❛t✐✈❡ P❛r❛♠❡t❡r✐③❛t✐♦♥ ❆♥ ❛❧t❡r♥❛t✐✈❡ ♣❛r❛♠❡t❡r✐③❛t✐♦♥ t♦ ❛ s❤❛r❡❞ r❛♥❞♦♠ ✐♥t❡r❝❡♣t ❛♣♣r♦❛❝❤ ✇❛s t♦ ❛❧❧♦✇ ❡❛❝❤ ❝♦♠♣♦♥❡♥t ♦❢ t❤❡ ❥♦✐♥t ♠♦❞❡❧ t♦ ❤❛✈❡ ✐ts ♦✇♥ r❛♥❞♦♠ ✐♥t❡r❝❡♣t t❡r♠✳ ❆ss♦❝✐❛t✐♦♥ ❜❡t✇❡❡♥ t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❛♥❞ s✉r✈✐✈❛❧ ♣r♦❝❡ss❡s ✇❛s t❤❡♥ ❝❛♣t✉r❡❞ ✐♥ ❛ s❤❛r❡❞ ❝♦✈❛r✐❛♥❝❡ t❡r♠✳ ❚❤❡ ❣❡♥❡r❛❧ ❢♦r♠s ❢♦r t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❛♥❞ s✉r✈✐✈❛❧ ♠♦❞❡❧s ❛r❡ t❤❡♥✿ Yij = Zijβ+ ai+ eij. ✭■❱✳✸✮ hi(t) = h0(t)exp(Wiα+ bi). ✭■❱✳✹✮ ◆♦t❛t✐♦♥ ❢♦r t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❝♦♠♣♦♥❡♥t r❡♠❛✐♥❡❞ ❝♦♥s✐st❡♥t ✇✐t❤ t❤❡ s❤❛r❡❞ r❛♥❞♦♠ ✐♥t❡r✲ ❝❡♣t ❛♣♣r♦❛❝❤ ♦❢ ❡q✉❛t✐♦♥ ■❱✳✶✳ ❋♦r t❤❡ s✉r✈✐✈❛❧ ❝♦♠♣♦♥❡♥t✱ t❤❡ s❤❛r❡❞ r❛♥❞♦♠ ✐♥t❡r❝❡♣t ❛♥❞ ❣❛♠♠❛ t❡r♠ ❢r♦♠ ❊q✉❛t✐♦♥ ■❱✳✷ ✇❡r❡ r❡♣❧❛❝❡❞ ❜② ❛ ✉♥✐q✉❡ r❛♥❞♦♠ ✐♥t❡r❝❡♣t t❡r♠✱ bi✱ ✇❤❡r❡ bi ∼ i.i.d◆✭✵✱ σ22)✳ ❚❤❡ ♠♦❞❡❧ t❤❡♥ s♦❧✈❡❞ ❢♦r t❤❡ ❝♦✈❛r✐❛♥❝❡ t❡r♠ Cov(ai✱bi)❜❡t✇❡❡♥ t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❛♥❞ s✉r✈✐✈❛❧ ♣r♦❝❡ss❡s ♦❢ ❡q✉❛t✐♦♥s ■❱✳✸ ❛♥❞ ■❱✳✹✳ ❲✐t❤ ✐♥✐t✐❛❧ ❡st✐♠❛t❡s ❢♦r ❛❧❧ ♣❛r❛♠❡t❡rs ❝♦♠✐♥❣ ❢r♦♠ t❤❡ ▼■❳❊❉ ❛♥❞ ▲■❋❊❘❊● ♣r♦❝❡✲ ❞✉r❡s✱ t❤❡ ♠♦❞❡❧ s♦❧✈❡❞ ❢♦r ❛ ❝♦✈❛r✐❛♥❝❡ t❡r♠ ♦❢ ✲✵✳✵✺✷✶ ✭♣❂✵✳✵✻✼✷✮✳ ❊①♣r❡ss❡❞ ❛s ❝♦rr❡❧❛✲ t✐♦♥✱ t❤❡ ✲✵✳✺✹✹✽ ✈❛❧✉❡ ✈❛❧✐❞❛t❡❞ t❤❡ ❣❛♠♠❛ r❡s✉❧ts ♦❢ ❤✐❣❤❡r ❋❊❱✶ r❡❛❞✐♥❣s ❜❡✐♥❣ ❛ss♦❝✐❛t❡❞ ✇✐t❤ ❢❡✇❡r ❞❡❛t❤s✳ ✶✶

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■❱✳✸ ❈♦♠♣❛r✐s♦♥ ♦❢ ❋✐①❡❞✲❊✛❡❝t ❚❡r♠ ❚❤❡ ❥♦✐♥t ♠♦❞❡❧ ❝♦♥✈❡r❣❡❞ ✇✐t❤ ❝♦♥s✐st❡♥t ❛♥❞ s✐❣♥✐✜❝❛♥t ✜♥❛❧ ❣❛♠♠❛ r❡s✉❧ts ✇❤❡♥ ✐♥✐✲ t✐❛❧ ❣❛♠♠❛ ✈❛❧✉❡s ✇❡r❡ ③❡r♦ ♦r s❧✐❣❤t❧② ♥❡❣❛t✐✈❡✳ ❯s✐♥❣ ❛ st❛rt✐♥❣ ❣❛♠♠❛ ❡st✐♠❛t❡ ♦❢ ✲✵✳✶✱ t❛❜❧❡ ■❱✳✷ s❤♦✇s ❛ ❝♦♠♣❛r✐s♦♥ ❜❡t✇❡❡♥ ❧♦♥❣✐t✉❞✐♥❛❧ ♣❛r❛♠❡t❡r ❡st✐♠❛t❡s ❢r♦♠ t❤❡ ❥♦✐♥t ♠♦❞❡❧ ❝♦♠♣❛r❡❞ t♦ ❧♦♥❣✐t✉❞✐♥❛❧ r❡s✉❧ts ♠♦❞❡❧❡❞ ✇✐t❤ ♥♦ ❛ss♦❝✐❛t✐♦♥ t♦ t❤❡ s✉r✈✐✈❛❧ ❝♦♠♣♦✲ ♥❡♥t✳ ❇♦t❤ ❛♥❛❧②③❡s ✇❡r❡ ❝♦❞❡❞ ✐♥ ◆▲▼■❳❊❉ ✉s✐♥❣ t❤❡ s❛♠❡ ❞❛t❛s❡t✱ ♥❛♠❡❧②✱ ♣❛rt✐❝✐♣❛♥ts ✇❤♦ ❤❛❞ ❋❊❱✶ r❡❛❞✐♥❣s ❢r♦♠ ❜♦t❤ ✈✐s✐ts ❛♥❞ ♣❛rt✐❝✐♣❛♥ts ✇✐t❤ ❛ ✈✐s✐t ✶ ❋❊❱✶ r❡❛❞✐♥❣ ❜✉t ✇❤♦ ❞✐❡❞ s♦♠❡t✐♠❡ ❜❡❢♦r❡ t❤❡ s❡❝♦♥❞ ✈✐s✐t✳ ❋♦r ❛❧❧ ✜①❡❞ ♣❛r❛♠❡t❡rs✱ t❤❡ st❛♥❞❛r❞ ❡rr♦r ✐♥❝r❡❛s❡❞ ✉♥❞❡r t❤❡ ❝♦rr❡❧❛t❡❞ ♠♦❞❡❧✳ ▲❡ss ♣r❡❝✐s✐♦♥ ✐♥ t❤❡ ❡rr♦r ❡st✐♠❛t❡s ♠❛② ❜❡ ❞✉❡ t♦ ❛ ✈❛❧✐❞ ✐♥✢✉❡♥❝❡ ♦❢ ❞❡❛t❤s ♦♥ t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ♣r♦❝❡ss ♦r ✐t ♠❛② ❜❡ t❤❡ ❡✛❡❝t ♦❢ t❤❡ ❛❞❞❡❞ ❝♦♠♣❧❡①✐t② ♦❢ t❤❡ ♠♦❞❡❧✳ ❚❤❡ ✈❛r✐❛♥❝❡ ♦❢ t❤❡ r❛♥❞♦♠ ✐♥t❡r❝❡♣t ❞✐❞ ♥♦t ❝❤❛♥❣❡ ❜❡t✇❡❡♥ t❤❡ s✐♠♣❧❡ ❛♥❞ ❝♦rr❡❧❛t❡❞ ♠♦❞❡❧s ❛s t❤❡ ✜♥❛❧ ❣❛♠♠❛ ♣❛r❛♠❡t❡r ♦❢ γ = −0.2477 (p = 0.0214) ❝❛♣t✉r❡❞ t❤❡ ❡✛❡❝t ♦❢ s✉r✈✐✈❛❧ ♦♥ t❤❡ r❛♥❞♦♠ ✐♥t❡r❝❡♣t t❡r♠✳ ❚❤❡ t♦t❛❧ ✐♠♣❛❝t ♦❢ t❤❡ ❥♦✐♥t ♠♦❞❡❧ ♦♥ ♦✈❡r❛❧❧ ❋❊❱✶ ❡st✐♠❛t✐♦♥ ❝❛♥ ❜❡ s❡❡♥ ✐♥ ❚❛❜❧❡ ■❱✳✸✳ ❋♦r ❛❧❧ st❛❣❡s✱ t❤❡ ❛✈❡r❛❣❡ st❛rt✐♥❣ ❋❊❱✶ ✈❛❧✉❡ ✇❛s s❧✐❣❤t❧② ❤✐❣❤❡r✱ ❝♦✉♣❧❡❞ ✇✐t❤ ❛ s❧✐❣❤t❧② st❡❡♣❡r ❞❡❝❧✐♥❡ ✐♥ ❋❊❱✶ ❜❡t✇❡❡♥ ✈✐s✐ts✳ Pr❛❝t✐❝❛❧❧②✱ t❤❡ ❝❤❛♥❣❡ ✐♥ ✈❛❧✉❡s ✇❛s s♠❛❧❧ ✭❧❡ss t❤❛♥ ✵✳✺✪✮ ❛♥❞ ❞✐❞ ♥♦t r❡♣r❡s❡♥t ❛ ♠❡❛♥✐♥❣❢✉❧ ❝❤❛♥❣❡ t♦ ❋❊❱✶ ♣r♦❣r❡ss✐♦♥ ❜② st❛❣❡✳ ❆s t❤❡ ❢♦❝✉s ♦❢ t❤❡ ❛♥❛❧②s✐s ✇❛s ♦♥ t❤❡ ❞❡✈❡❧♦♣♠❡♥t ♦❢ ❛ ❣❛♠♠❛ ♣❛r❛♠❡t❡r ❛♥❞ ❛♥② ✐♠♣❛❝t t♦ ❧♦♥❣✐t✉❞✐♥❛❧ ❡st✐♠❛t❡s✱ r❡s✉❧ts ❢♦r t❤❡ s✉r✈✐✈❛❧ ❝♦♠♣♦♥❡♥t ✇❡r❡ ♥♦t r❡✈✐❡✇❡❞✳ ✶✷

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❚❛❜❧❡ ■❱✳✷✿ ▲♦♥❣✐t✉❞✐♥❛❧ ♣❛r❛♠❡t❡r ❝♦♠♣❛r✐s♦♥ ❜❡t✇❡❡♥ s✐♠♣❧❡ ❛♥❞ ❥♦✐♥t ♠♦❞❡❧s✳ ❇♦t❤ ❛r❡ ❝♦❞❡❞ ✐♥ ◆▲▼■❳❊❉ ✉s✐♥❣ t❤❡ s❛♠❡ ❞❛t❛s❡t ♦❢ ♣❛rt✐❝✐♣❛♥ts✳ ❚❤❡ s✐♠♣❧❡ ♠♦❞❡❧ ✐s ❛ st❛♥❞ ❛❧♦♥❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❛♥❛❧②s✐s✳ ❚❤❡ ❥♦✐♥t ♠♦❞❡❧ ✉s❡s ❛ st❛rt✐♥❣ ❣❛♠♠❛ ❡st✐♠❛t❡ ♦❢ ✲✵✳✶✳ ▲♦♥❣✐t✉❞✐♥❛❧ ❙✐♠♣❧❡ ❏♦✐♥t P❛r❛♠❡t❡r ❊st✐♠❛t❡ ✭❙✳❊✳✮ ❊st✐♠❛t❡ ✭❙✳❊✳✮ ❈❤❛♥❣❡ ♣✲✈❛❧✉❡ β0 ✭❙t❛❣❡ ✹✮ ✵✳✾✵✾✵ ✭✵✳✷✾✽✵✮ ✶✳✵✷✹✸ ✭✵✳✸✵✽✵✮ ✰✶✷✳✼✪✭✰✸✳✹✪✮ ✵✳✵✵✵✾ ❱✐s✐t ❉❛t❡ ✵✳✵✵✵✵ ✭✵✳✵✵✵✵✮ ✵✳✵✵✵✵ ✭✵✳✵✵✵✵✮ ✰✹✶✳✼✪✭✰✸✳✹✪✮ ✵✳✷✵✻✷ P❘■❙♠ ✷✳✵✻✺✸ ✭✵✳✸✹✼✽✮ ✷✳✵✼✸✶ ✭✵✳✸✺✶✸✮ ✰✵✳✹✪✭✰✶✳✵✪✮ <0.0001 ❙t❛❣❡✵ ✹✳✵✵✽✺ ✭✵✳✸✶✶✶✮ ✹✳✵✺✶✶ ✭✵✳✸✶✺✽✮ ✰✶✳✶✪✭✰✶✳✺✪✮ <0.0001 ❙t❛❣❡✶ ✹✳✹✽✼✵ ✭✵✳✸✺✻✽✮ ✹✳✹✽✾✸ ✭✵✳✸✻✵✾✮ ✰✵✳✶✪✭✰✶✳✶✪✮ <0.0001 ❙t❛❣❡✷ ✸✳✶✹✽✹ ✭✵✳✸✷✹✾✮ ✸✳✶✻✽✼ ✭✵✳✸✷✽✽✮ ✰✵✳✻✪✭✰✶✳✷✪✮ <0.0001 ❙t❛❣❡✸ ✶✳✹✻✻✺ ✭✵✳✸✹✹✶✮ ✶✳✹✽✸✼ ✭✵✳✸✹✻✻✮ ✰✶✳✷✪✭✰✵✳✼✪✮ <0.0001 P❘■❙♠✯❉❛t❡ ✵✳✵✵✵✵ ✭✵✳✵✵✵✵✮ ✵✳✵✵✵✵ ✭✵✳✵✵✵✵✮ ✰✵✳✾✪✭✰✶✳✵✪✮ ✵✳✵✺✸✻ ❙t❛❣❡✵✯❉❛t❡ ✲✵✳✵✵✵✶ ✭✵✳✵✵✵✵✮ ✲✵✳✵✵✵✶ ✭✵✳✵✵✵✵✮ ✰✷✳✵✪✭✰✶✳✺✪✮ <0.0001 ❙t❛❣❡✶✯❉❛t❡ ✲✵✳✵✵✵✶ ✭✵✳✵✵✵✵✮ ✲✵✳✵✵✵✶ ✭✵✳✵✵✵✵✮ ✰✵✳✵✪✭✰✶✳✷✪✮ <0.0001 ❙t❛❣❡✷✯❉❛t❡ ✲✵✳✵✵✵✶ ✭✵✳✵✵✵✵✮ ✲✵✳✵✵✵✶ ✭✵✳✵✵✵✵✮ ✰✵✳✽✪✭✰✶✳✷✪✮ <0.0001 ❙t❛❣❡✸✯❉❛t❡ ✲✵✳✵✵✵✶ ✭✵✳✵✵✵✵✮ ✲✵✳✵✵✵✶ ✭✵✳✵✵✵✵✮ ✰✶✳✻✪✭✰✵✳✼✪✮ ✵✳✵✵✷✼ ●❛♠♠❛ ♥✴❛ ✲✵✳✷✹✼✼ ✭✵✳✶✵✼✻✮ ♥✴❛ ✵✳✵✷✶✹ ❱❛r ai ✵✳✷✻✻✼ ✵✳✷✻✻✼ ✭✵✳✵✵✽✵✮ ✰✵✳✵✪ <0.0001 ❱❛r ei ✵✳✵✸✽✵ ✵✳✵✸✽✶ ✭✵✳✵✵✶✷✮ ✰✵✳✷✪ <0.0001 ❚❛❜❧❡ ■❱✳✸✿ ❆✈❡r❛❣❡ ❋❊❱✶ r❡s✉❧ts ❜② st❛❣❡ ❢♦r ❜♦t❤ t❤❡ s✐♠♣❧❡ ❛♥❞ ❥♦✐♥t ♠♦❞❡❧s✳ ❚✐♠❡ ✐s ❝❛❧❝✉❧❛t❡❞ ❛s ❞❛②s ✇✐t❤ ✈✐s✐t ✷ ♦❝❝✉rr✐♥❣ ❛t t❤❡ ❛✈❡r❛❣❡ ❞✉r❛t✐♦♥ ♦❢ ✹✳✾✻ ②❡❛rs✳ ❱✐s✐t ✶ ❱✐s✐t ✷ ❉✐✛❡r❡♥❝❡ P❘■❙♠ ❯♥❝♦rr❡❧❛t❡❞ ✷✳✵✹✻✹ ✶✳✾✺✷✼ ✲✵✳✵✾✸✻ ❈♦rr❡❧❛t❡❞ ✷✳✵✺✶✵ ✶✳✾✹✺✺ ✲✵✳✶✵✺✻ ❙t❛❣❡ ✵ ❯♥❝♦rr❡❧❛t❡❞ ✷✳✽✹✻✺ ✷✳✻✸✼✻ ✲✵✳✷✵✾✵ ❈♦rr❡❧❛t❡❞ ✷✳✽✺✺✺ ✷✳✻✸✶✺ ✲✵✳✷✷✹✵ ❙t❛❣❡ ✶ ❯♥❝♦rr❡❧❛t❡❞ ✷✳✻✶✽✾ ✷✳✸✸✽✺ ✲✵✳✷✽✵✹ ❈♦rr❡❧❛t❡❞ ✷✳✻✷✷✵ ✷✳✸✸✵✷ ✲✵✳✷✾✶✽ ❙t❛❣❡ ✷ ❯♥❝♦rr❡❧❛t❡❞ ✶✳✽✸✽✻ ✶✳✻✶✹✽ ✲✵✳✷✷✸✾ ❈♦rr❡❧❛t❡❞ ✶✳✽✹✻✻ ✶✳✻✵✾✽ ✲✵✳✷✸✻✽ ❙t❛❣❡ ✸ ❯♥❝♦rr❡❧❛t❡❞ ✶✳✶✵✵✻ ✵✳✾✼✷✵ ✲✵✳✶✷✽✻ ❈♦rr❡❧❛t❡❞ ✶✳✶✵✹✷ ✵✳✾✻✷✺ ✲✵✳✶✹✶✻ ❙t❛❣❡ ✹ ❯♥❝♦rr❡❧❛t❡❞ ✵✳✻✸✽✺ ✵✳✻✶✶✷ ✲✵✳✵✷✼✸ ❈♦rr❡❧❛t❡❞ ✵✳✻✹✵✾ ✵✳✻✵✷✷ ✲✵✳✵✸✽✼ ✶✸

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❈❍❆P❚❊❘ ❱ ❚❲❖✲P❆❘❚ ▼❖❉❊▲ ❱✳✶ ◆♦t❛t✐♦♥ ❆ t✇♦✲♣❛rt ♠♦❞❡❧ ❝♦♥s✐❞❡rs ❞❡❛t❤ ❛s ❛ s❡♣❛r❛t❡ ❞✐❝❤♦t♦♠♦✉s ♦✉t❝♦♠❡✳ ❚❤❡ ♠♦❞❡❧ ❝♦♥✲ t❛✐♥s t✇♦ ❝♦♠♣♦♥❡♥ts✱ t❤❡ ❧♦❣✐st✐❝ s❡❣♠❡♥t ♠♦❞❡❧✐♥❣ t❤❡ ♣r♦❜❛❜✐❧✐t② ♦❢ ❞❡❛t❤ ❛♥❞ t❤❡ ♥♦r♠❛❧ s❡❣♠❡♥t ♠♦❞❡❧✐♥❣ t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❞❡❝❧✐♥❡ ✐♥ ❋❊❱✶✳ ❚❤❡ r❡s✉❧t ✐s ❛ ♠✐①❡❞✲❞✐str✐❜✉t✐♦♥ ♠♦❞❡❧ ✇❤❡r❡ ❡❛❝❤ ❝♦♠♣♦♥❡♥t ❤❛s ✐ts ♦✇♥ r❛♥❞♦♠ ❡✛❡❝t ❛♥❞ ❝♦rr❡❧❛t✐♦♥ ❜❡t✇❡❡♥ t❤❡ t✇♦ ♣✐❡❝❡s ✐s ❝❛♣t✉r❡❞ ✐♥ ❛ s❤❛r❡❞ ❝♦✈❛r✐❛♥❝❡ t❡r♠✳ ❯t✐❧✐③✐♥❣ ♥♦t❛t✐♦♥ ♣r♦✈✐❞❡❞ ❜② ♣r✐♦r ❛✉t❤♦rs ✭❚♦♦③❡ ❡t ❛❧✳✱✷✵✵✷✮✱ t❤❡ ♠♦❞❡❧ ✐s ❡①♣r❡ss❡❞ ❛s✿ Yij ❂ ❚❤❡ ❋❊❱✶ ♦❢ s✉❜❥❡❝t i ❛t t✐♠❡ j ✇❤❡r❡ j = 1, 2 Rij ❂ ❚❤❡ ♦❝❝✉rr❡♥❝❡ ♦❢ ❋❊❱✶ ❢♦r s✉❜❥❡❝t i ❛t t✐♠❡ j ✇❤❡r❡ j = 1, 2 ❛♥❞ Rij =  0 ✐❢ Yij = 0 ✭❞❡❛t❤✮, 1 ✐❢ Yij >0 ❚❤❡ ❣❡♥❡r❛❧ ❢♦r♠s ♦❢ t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❝♦♠♣♦♥❡♥t ❢♦r ❋❊❱✶ ♣r♦❣r❡ss✐♦♥ ❛♥❞ t❤❡ ❧♦❣✐st✐❝ ♠♦❞❡❧ ❢♦r ♦❝❝✉rr❡♥❝❡ ♦❢ ❛ ♣♦s✐t✐✈❡ ❋❊❱✶ r❡❛❞✐♥❣ ❛r❡✿ (Yij|Rij = 1) = Zijβ1+ ai+ eij. ✭❱✳✶✮ logit(pij) = Xijβ2+ bi. ✭❱✳✷✮ ❊q✉❛t✐♦♥ ❱✳✶ ❢♦r t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ♠♦❞❡❧ ✐s t❤❡ s❛♠❡ ❛s ❡q✉❛t✐♦♥ ■❱✳✶ ✉♥❞❡r t❤❡ ❥♦✐♥t ♠♦❞❡❧ ✇❤❡r❡ Zij ✐s t❤❡ ❝♦✈❛r✐❛t❡ ✈❡❝t♦r ❢♦r s✉❜❥❡❝t i ❛t t✐♠❡ j✱ β ✐s ❛ ♣❛r❛♠❡t❡r ✈❡❝t♦r✱ ai ✐s ❛ s✉❜❥❡❝t s♣❡❝✐✜❝ r❛♥❞♦♠ ✐♥t❡r❝❡♣t t❡r♠ ✇❤❡r❡ ai ∼ i.i.d ◆✭✵✱ σ12✮ ❛♥❞ eij ✐s t❤❡ ❡rr♦r t❡r♠ ✇❤❡r❡ eij ∼ i.i.d◆✭✵✱ σ2e✮✳ ❋♦r t❤❡ ❧♦❣✐st✐❝ ♠♦❞❡❧ ✭❱✳✷✮✱ Xij ✐s ❛ ❝♦✈❛r✐❛t❡ ✈❡❝t♦r ❢♦r s✉❜❥❡❝t i❛t t✐♠❡ j✱ ❛♥❞ bi✐s ❛ s✉❜❥❡❝t s♣❡❝✐✜❝ r❛♥❞♦♠ ✐♥t❡r❝❡♣t t❡r♠ ✇❤❡r❡ bi ∼ i.i.d◆✭✵✱ σ 2 2✮✳ ❚❤❡ r❛♥❞♦♠ ❡✛❡❝ts ❢♦r t❤❡ ♦❝❝✉rr❡♥❝❡ ❛♥❞ ✐♥t❡♥s✐t② ♦❢ ❋❊❱✶ ❛r❡ ❝♦rr❡❧❛t❡❞ ❜② ❛ss✉♠✐♥❣ t❤❛t✿ ✶✹

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ai bi  ∼ N00  ,  σ2 1 ρσ 1 1σ 2 2 ρσ1 1σ 2 2 σ 2 2  ❈♦❞❡ ❢r♦♠ ✭❚♦♦③❡ ❡t ❛❧✳✱ ✷✵✵✷✮ ✇❛s ✐♠♣❧❡♠❡♥t❡❞ ✐♥ t❤❡ ◆▲▼■❳❊❉ ♣r♦❝❡❞✉r❡✳ ❙✐♠✐❧❛r t♦ t❤❡ ❥♦✐♥t ♠♦❞❡❧✱ ❝♦♥✈❡r❣❡♥❝❡ ✇❛s ❞✐✣❝✉❧t ✇✐t❤♦✉t r❡❛s♦♥❛❜❧❡ ❡st✐♠❛t❡s ❢♦r t❤❡ st❛rt✐♥❣ ♣❛r❛♠❡t❡rs ✐♥ t❤❡ ❝♦rr❡❧❛t❡❞ ♠♦❞❡❧✳ ■♥✐t✐❛❧ ❡st✐♠❛t❡s ❢♦r ❜♦t❤ t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❛♥❞ ❧♦❣✐st✐❝ ❝♦♠♣♦♥❡♥ts ✇❡r❡ ✜rst ❞❡✈❡❧♦♣❡❞ s❡♣❛r❛t❡❧② ✐♥ t❤❡ ●❊◆▼❖❉ ♣r♦❝❡❞✉r❡✳ ❚❤❡ ❞❛t❛s❡t ✇❛s t❤❡ s❛♠❡ ❛s t❤❛t ✉s❡❞ ❢♦r t❤❡ ❥♦✐♥t ♠♦❞❡❧ ❛♥❛❧②s✐s ✐♥ t❤❛t ♠✐ss✐♥❣ s✉❜❥❡❝ts ❛♥❞ t❤♦s❡ ✇❤♦ ❞r♦♣♣❡❞ ♦✉t ♦❢ t❤❡ st✉❞② ✇❡r❡ r❡♠♦✈❡❞✳ ■♥✐t✐❛❧❧②✱ t❤❡ ❝♦✈❛r✐❛t❡s ❢♦r t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❝♦♠♣♦✲ ♥❡♥t ❢♦❝✉s❡❞ ♦♥ t❤❡ s❛♠❡ ❝♦✈❛r✐❛t❡s ✉t✐❧✐③❡❞ ✐♥ t❤❡ ❥♦✐♥t ♠♦❞❡❧✿ ●❖▲❉ st❛❣❡✱ ✈✐s✐t ❞❛t❡✱ ❛♥❞ t❤❡ ✐♥t❡r❛❝t✐♦♥ ❜❡t✇❡❡♥ st❛❣❡ ❛♥❞ ✈✐s✐t ❞❛t❡✳ ❚✐♠❡ ✇❛s tr❡❛t❡❞ ❛s ❛ ❞✐❝❤♦t♦♠♦✉s ✈❛r✐❛❜❧❡ ✭✈✐s✐t ✶ ♦r ✷✮ ❛♥❞ ♥♦t ❛ ❝♦♥t✐♥✉♦✉s ♦♥❡ ❜❛s❡❞ ♦♥ ❞❛t❡✳ ▲♦♥❣✐t✉❞✐♥❛❧ ❛♥❛❧②s✐s ❞❡♠♦♥str❛t❡❞ ♥♦ s✐❣♥✐✜❝❛♥t ❞✐✛❡r❡♥❝❡ ❜❡t✇❡❡♥ tr❡❛t✐♥❣ t✐♠❡ ❛s ❝♦♥t✐♥✉♦✉s ✈❡rs✉s ❞✐❝❤♦t♦♠♦✉s✳ ❋♦r t❤❡ ❜✐♥♦♠✐❛❧ ❝♦♠♣♦♥❡♥t✱ ✈✐s✐t ❞❛t❡ ❛♥❞ st❛❣❡ ✇❡r❡ t❤❡ ♦♥❧② ❝♦✈❛r✐❛t❡s✳ ❲✐t❤ t❤❡ r❡❞✉❝❡❞ ❝♦✈❛r✐✲ ❛t❡ s❡ts✱ r❡s✉❧ts ❢♦r t❤❡ ❝♦rr❡❧❛t❡❞ ♠♦❞❡❧ ✇❡r❡ ❡rr❛t✐❝✱ ❛♥❞ ♦♣t✐♠✐③❛t✐♦♥ ✇❛s ♥♦t ❝♦♥s✐st❡♥t❧② ❛❝❤✐❡✈❡❞✳ ▼♦❞❡❧ s❡❧❡❝t✐♦♥ ✇❛s t❤❡♥ ✉s❡❞ t♦ ✜♥❞ t❤❡ ♦♣t✐♠❛❧ s❡t ♦❢ ❝♦✈❛r✐❛t❡s ❢♦r t❤❡ ❜✐♥♦♠✐❛❧ ❛♥❞ ❧♦♥❣✐t✉❞✐♥❛❧ ♠♦❞❡❧s s❡♣❛r❛t❡❧②✳ ❚❤❡ s❡t ♦❢ s✐❣♥✐✜❝❛♥t ❝♦✈❛r✐❛t❡s ❢♦r t❤❡ ❜✐♥♦♠✐❛❧ ♠♦❞❡❧ ✐♥✲ ❝❧✉❞❡❞ ✈✐s✐t ❞❛t❡✱ s❡①✱ ❛♥❞ ❜❛s❡❧✐♥❡ ✈❛❧✉❡s ❢♦r ●❖▲❉ st❛❣❡✱ ❛❣❡✱ ❇▼■✱ s♠♦❦✐♥❣ st❛t✉s✱ ❛♥❞ ✇❤❡t❤❡r ♦r ♥♦t t❤❡ s✉❜❥❡❝t ❤❛❞ ❡①♣❡r✐❡♥❝❡❞ s❡✈❡r❡ ❡①❛❝❡r❜❛t✐♦♥s ✐♥ t❤❡ ✻ ♠♦♥t❤s ♣r✐♦r t♦ t❤❡✐r ✜rst ✈✐s✐t✳ ❆♥ ✐♥t❡r❛❝t✐♦♥ t❡r♠ ❜❡t✇❡❡♥ ✈✐s✐t ❞❛t❡ ❛♥❞ ❜❛s❡❧✐♥❡ s♠♦❦✐♥❣ st❛t✉s ✇❛s ❛❧s♦ ✐♥❝❧✉❞❡❞✱ r❡s✉❧t✐♥❣ ✐♥ ❛ t♦t❛❧ ♦❢ ❢♦✉rt❡❡♥ ❞✐✛❡r❡♥t ♣r❡❞✐❝t♦rs✳ ❋♦r t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ♠♦❞❡❧✱ t❤❡ ✜♥❛❧ s❡t ♦❢ ❝♦✈❛r✐❛t❡s ✐♥❝❧✉❞❡❞ t❤❡ ✈✐s✐t ❞❛t❡✱ s❡①✱ ❛♥❞ ❜❛s❡❧✐♥❡ ✈❛❧✉❡s ❢♦r ●❖▲❉ st❛❣❡✱ ❛❣❡✱ ❛♥❞ ❛♥ ❡♠♣❤②s❡♠❛ ✐♥❞✐❝❛t♦r✳ ❚✐♠❡ s❡♥s✐t✐✈❡ ✈❛r✐❛❜❧❡s ✐♥❝❧✉❞❡❞ ❇▼■✱ r❡❝❡♥t ♦❝❝✉rr❡♥❝❡ ♦❢ s❡✈❡r❡ ❡①❛❝❡r❜❛t✐♦♥s✱ s♠♦❦✐♥❣ st❛t✉s✱ ❛♥❞ t❤r❡❡ st❛♥❞❛r❞ ♣✉❧♠♦♥❛r② ♠❡❞✐❝❛t✐♦♥s✳ ■♥t❡r❛❝✲ t✐♦♥ t❡r♠s ❜❡t✇❡❡♥ ✈✐s✐t ❞❛t❡ ❛♥❞ ❜♦t❤ ●❖▲❉ st❛❣❡ ❛♥❞ s♠♦❦✐♥❣ st❛t✉s ✇❡r❡ ❛❧s♦ ✐♥❝❧✉❞❡❞✳ ❚❤✐s r❡s✉❧t❡❞ ✐♥ ❛ t♦t❛❧ s❡t ♦❢ t✇❡♥t②✲t❤r❡❡ ❝♦✈❛r✐❛t❡s ❢♦r t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❝♦♠♣♦♥❡♥t✳ ✶✺

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❱✳✷ ▼♦❞❡❧ ❘❡s✉❧ts ❚❛❜❧❡ ❱✳✶ s❤♦✇s ❛ ❝♦♠♣❛r✐s♦♥ ❜❡t✇❡❡♥ t❤❡ ♣❛r❛♠❡t❡rs ❢r♦♠ ❛ s✐♠♣❧❡ ❧♦♥❣✐t✉❞✐♥❛❧ ♠♦❞❡❧ ❝♦♠♣❛r❡❞ t♦ t❤❡ s❛♠❡ ❧♦♥❣✐t✉❞✐♥❛❧ ♣r❡❞✐❝t♦rs ❢r♦♠ t❤❡ t✇♦✲♣❛rt ♠♦❞❡❧✳ ❚❤❡ ❜✐❣❣❡st ❞✐✛❡r✲ ❡♥❝❡s ❜❡t✇❡❡♥ t❤❡ t✇♦ ❛♣♣r♦❛❝❤❡s ❛✛❡❝t❡❞ t❤❡ ❞✐❝❤♦t♦♠♦✉s ♣❛r❛♠❡t❡r ❢♦r ✈✐s✐t✱ ❛s ✇❡❧❧ ❛s t❤❡ ✐♥t❡r❛❝t✐♦♥ t❡r♠s ❜❡t✇❡❡♥ st❛❣❡ ❛♥❞ ✈✐s✐t✳ ■♥✐t✐❛❧ ❡st✐♠❛t❡s ❢♦r t❤❡ r❛♥❞♦♠ ❡✛❡❝t t❡r♠s ♦❢ ❜♦t❤ t❤❡ ❧♦♥❣✐t✉❞✐♥❛❧ ❛♥❞ ❜✐♥♦♠✐❛❧ ❝♦♠♣♦♥❡♥ts r❡♠❛✐♥❡❞ r❡❧❛t✐✈❡❧② ✉♥❝❤❛♥❣❡❞✿ ❧❡ss t❤❛♥ ❛ ✵✳✷✪ ❝❤❛♥❣❡ ❢♦r ❧♦♥❣✐t✉❞✐♥❛❧✱ ❛♥❞ ❛ ✲✸✳✹✪ ❞❡❝r❡❛s❡ ❢♦r ❧♦❣✐st✐❝✳ ❚❤❡ ❝♦✈❛r✐❛♥❝❡ t❡r♠ ❜❡✲ t✇❡❡♥ t❤❡ t✇♦ ❝♦♠♣♦♥❡♥ts ♦❢ t❤❡ ♠♦❞❡❧ ♦❢ ✵✳✵✻✹✻ ✭♣❂✵✳✵✶✺✺✮ ✐♥❞✐❝❛t❡s t❤♦s❡ ✇✐t❤ ❤✐❣❤❡r ❋❊❱✶ ✈❛❧✉❡s ❛r❡ ♠♦r❡ ❧✐❦❡❧② t♦ ❤❛✈❡ ❛ s❡❝♦♥❞ ❋❊❱✶ r❡❛❞✐♥❣✳ ❈♦♥✈❡rt✐♥❣ t❤❡ ❝♦✈❛r✐❛♥❝❡ t♦ ❝♦rr❡❧❛t✐♦♥ ②✐❡❧❞s ❛ ✈❛❧✉❡ ♦❢ ✵✳✷✸✷✸✳ ❚❛❦❡♥ t♦❣❡t❤❡r✱ ❛❞♦♣t✐♦♥ ♦❢ t❤❡ t✇♦✲♣❛rt ♠♦❞❡❧ ♠♦❞✐✜❡❞ t❤❡ ❋❊❱✶ tr❛❥❡❝t♦r✐❡s ❜② st❛❣❡ t♦ ♦♥❧② ❛ s♠❛❧❧ ❞❡❣r❡❡✳ ❚❛❜❧❡ ❱✳✷ s❤♦✇s t❤❡ ❝❤❛♥❣❡ ✐♥ ❋❊❱✶ ❢r♦♠ ✈✐s✐t ✶ t♦ ✈✐s✐t ✷ ❜② st❛❣❡ ❢♦r ❛♥ ❛✈❡r❛❣❡ ♠❛❧❡ s✉❜❥❡❝t ❜② s♠♦❦✐♥❣ st❛t✉s✳ ▼❡❛♥ ❡♥r♦❧❧♠❡♥t ✈❛❧✉❡s ❢♦r ❛❣❡ ✭✻✶✮✱ ❇▼■ ✭✷✽✮✱ ❛♥❞ ❤❡❛❧t❤ st❛t✉s ✭♥♦ ❡①❛❝❡r❜❛t✐♦♥s ♦r ❛st❤♠❛ ♠❡❞✐❝❛t✐♦♥s✮ ✇❡r❡ ✉s❡❞✳ ▲✐st❡❞ ✐♥ t❤❡ ✜rst t❤r❡❡ ❝♦❧✉♠♥s ♦❢ t❤❡ t❛❜❧❡ ❛r❡ r❡s✉❧ts ❢♦r s✉❜❥❡❝ts ✇❤♦ ✇❡r❡ ♥♦t ❝✉rr❡♥t❧② s♠♦❦✐♥❣ ✭♥♦♥ ♦r ❢♦r♠❡r s♠♦❦❡rs✮ ❛t t❤❡ t✐♠❡ ♦❢ ❡♥r♦❧❧♠❡♥t✳ ❆s ✇✐t❤ t❤❡ ❥♦✐♥t ♠♦❞❡❧✱ t❤❡ ❢♦❝✉s ♦❢ t❤❡ ❛♥❛❧②s✐s ✇❛s ♦♥ t❤❡ ❞❡✈❡❧♦♣♠❡♥t ♦❢ ❛ ❝♦✈❛r✐❛♥❝❡ ♣❛r❛♠❡t❡r ❛♥❞ ❛♥② ✐♠♣❛❝t t♦ ❧♦♥❣✐t✉❞✐♥❛❧ ❡st✐♠❛t❡s✳ ❚❤✉s✱ r❡s✉❧ts ❢♦r t❤❡ ❜✐♥♦♠✐❛❧ ❝♦♠♣♦♥❡♥t ✇❡r❡ ♥♦t r❡✈✐❡✇❡❞✳ ✶✻

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