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Molecular Biotechnology Programme Uppsala University School of Engineering

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Molecular Biotechnology Programme

Uppsala University School of Engineering

UPTEC X 06 010 Date of issue 2006-02 Author

Sandra Andersson

Title (English)

Chimeric T cell receptors

Title (Swedish) Abstract

The goal of effective immunotherapy is to restore the immune system’s natural ability to recognize and eliminate transformed cells. The aim of this project was to develop a chimeric T cell receptor which would give the cytotoxic T lymphocytes a higher efficiency in destroying tumor cells. The chimeric T cell receptor was constructed by the fusion of the variable region of an antigen together with the intracellular part from an original T cell receptor.

Keywords

Bladder carcinoma, immune surveillance, immune escape, immunotherapy, chimeric T cell receptors, retroviral vector

Supervisors

Angelica Loskog

Division of Clinical Immunology, Uppsala University

Scientific reviewer

Thomas Tötterman

Division of Clinical Immunology, Uppsala University

Project name Sponsors

Language

English

Security

ISSN 1401-2138 Classification

Supplementary bibliographical information Pages

26

Biology Education Centre Biomedical Center Husargatan 3 Uppsala Box 592 S-75124 Uppsala Tel +46 (0)18 4710000 Fax +46 (0)18 555217

References

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