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Bioinformatics Engineering Program Uppsala University School of Engineering

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Bioinformatics Engineering Program

Uppsala University School of Engineering

UPTEC X 08 044 Date of issue 2009-03

Author

Elin V. Falk

Title (English)

Analyses of Gene Expression Patterns in Colon Cancer Patients

Title (Swedish)

Abstract

The aim of this project was to investigate if any differences in the gene expression pattern between colon cancer patients with mutations in certain codons in BRAF, KRAS and PIK3CA could be detected. The samples were classified as mutated or wild type with a support vector machine and either of two feature selection setups, ANOVA or a combination of ANOVA and genetic algorithm.

Differences in the gene expression pattern were found in BRAF and PIK3CA, both between the mutated and wild type patients and between the different Dukes’ stages in the mutated samples.

Keywords

ANOVA, Bioinformatics, Dukes' stage, Genetic Algorithm, Support vector machine

Supervisors

Dr. Daniel Crowther

Translation Medicine Research Collaboration, Dundee

Scientific reviewer

Dr. Lee Larcombe

Cranfield University, School of Health

Project name Sponsors

Scottish Bioinformatics Forum Language

English

Security

ISS4 1401-2138 Classification

Supplementary bibliographical information

Pages

108

References

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