Compartmental models of lipoprotein kinetics

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(50) ]M ^`R]QNO\]G N ]M RU XGJM ( ^ NO\[NO\^àxaOGJN ]I NO\]G n e F e KXR[n e F e IU U alK5MOG/^`R[G ^ ^`M ^ P KXRL K5MOG/K P/U aN _ U RaNOKXR Nz

(51) ]M ^`R] NO\G aON msRNO\G _ KXP/I aN XKD_ U RaNOKXR Nz^`Ra ^`R^` R ,GS_ NO^ U R"^àHaNOK5MONGS 5PQ^ R ]NGSalGJW UXM G NO\GANM KX_ GJM azK5MOG ^` R ,GS_ NGS- ZmsRTNM K XGSR]U ax _ U aGA^à, !^ XGSR>NU XGJGJINO\]GzI KXaOPQK _ U aOG G XG aV_ U RLaNOKXRTN r U^`#R XGSaNO^ K5NG"NO\]G ~^`R]GJNO^`_JaJlK_ U PAL^`R]GS=P NO^x_ U PQILK5MONOP/GSR NOK P/U~]G ,KXaD]G XG UXIGS- rV\]G P/U~]G _ U RLaO^àNOaAUXWVaG XGJM K a ]$ P/UqG a x\^ _ \]GSa _ M ^ GQNO\]G q^`RGJNO^`_JazUXWVNO\G NM KX_ GJM a GJW UXMOG NO\]G K5MOG/^`R_ UXM I UXM K5NGS^`R NU*NO\]G ^ IUXIMOUXNGS^`RILK5MONO^`_ GSa iqU PQGAUXWNO\]GSaG a ] P/U~]G aH_ U GCMOGJI KX_ GS W UXM _J^`R]DW R_ NO^ U RLalUXM [UXNO\]GJMCa ]$ P/UqG al^`WhUXNO\]GJMzNM KX_ GJM azK5MOG aOGS"UXMC^ W NO\]G/+G ~IGJM ^`P/GSR NOK aGJN ]I^à P/U~&^ .LGS- msRNO\]G ^Ì UXILMOUXNGS^`RDP/U~]G ]GSKX_ \[_ U P/ILK5M NOP/GSRTNH_ UXMOMOGSaIU RLa,NU KQ_ U GS_ NO^ U R>UXW ^ IUXIM UXNGS^`R*ILK5MONO^ _ GSa x^ NO\DK .

(52) ~GS a ^ JGX]]+G . R]GS* QNO\]G KXP/U R N,UXW NM ^ ~_ GJM ^`GSahIGJM,ILK5MONO^`_ G rx\]GHPQUq]G _ U RaO^ aNOa UXW NO\]G G K5NO^ U Rap]GSa _ M ^ L^`RQNO\]G ~GSalUXWPQK5NGJM ^`K ( ILK5MONO^ _ GSapKXRNM ^ ~_ GJM ^`]GSa * GJN GJGSR _ U P ILK5MONOPQGSRTNOa ZrV\GVM K5NGVUXW_ \LKXR]XGxUXWPQK5NGJM ^ K ^`R/Kz_ U PQILK5MONOP/GSR N^à NO\]Gx&^ %GJMOGSR_ G UXWNO\]GxW M KX_ NO^Ù RK NM KXRaOW GJMpW MOU P K UXNO\GJMp_ U PQILK5MONOP/GSR NOa KXR[NO\]G W M KX_ NO^Ù RK NM KXRaW GJMlW MOU P NO\]G _ U P/ILK5MONOPQGSRTN zmsR NO\^à K5II ^`_JK5NO^ U RNO\G W M KX_ NO^ U RK NM KXRLaW GJM _ UqG _J^ GSR NOa/K5MOG*_ U RLaO^`]GJMOGSNU"G ^`RGJI GSRL]GSRTNCUXWVNO\]G _ U P/ILK5M NOP/GSRTNOK PQKXaOaGSaSLKXR>K5MOG M GJ K5M ]GSKXax_ U RaNOKXR NxUXMVNO^`PQGz]GJIGSR]GSR N rV\]G[]GJM !^ XGS=P/U~]G _ U PAL^`RGSa No UP/U~]G a W UXM*NO\]G[N UL&^ % GJM GSRTN NM KX_ GJM a*NU ^ XG[KP/UXMOG"]G NOKX^ GSGSaO_ M ^ INO^Ù RUXWlNO\]G q^`RGJNO^`_JaJ_ U PQILK5MOGSNU PQUq]G a x^ NO\U R]G>NM KX_ GJM rV\]G>^ ]GSKXa/GS\^`R NO\]G/_ U PAL^`RK5NO^ U RUXWhNO\G P/U~]G aH_ U [MOGSKXL^ GAK5II ^ GS>NU+G ~IGJM ^`P/GSR NOal x^ NO\[P/UXMOG NO\KXR"N U.

(53) NM KX_ GJM am}NxK aOU K U xaVW UXMxUXNO\]GJMlNM KX_ GJM alNU G/aOGS-rV\GCP/U~]G ^`R_ ]GSa,n e F e KXRn e F e ]NA_JKXRGQ+G ~NGSR]GSNU[^`R_ L]G m}F e KXR e F e KXaz G ( G ^ RXGSaNO^` K5NG ^`]GSR NO^&. K5 ^ ^ N>UXW NO\]G P/U~]G a,KXRD\]U aGHUXW IUXI K5NO^Ù R K XGJM K5XGSaVW UXM aU P/G NM KXRaOW GJM _ UqG _J^ GSR NOaV^`P/ILKX_ NOaNO\]GpMOGSa NOa B . * . . rV\^ aVNO\]GSaO^ al_ U R NOKX^`Ra K*PQKX^`RILK5MONH x\]GJMOGANO\]G P/UqG ^`R] ^àlGSaO_ M ^ GS>^`R[]GJNOKX^ HrV\GAP/U~]G \KXa GJGSR>K5II ^ GSDNU G+~IGJM ^`P/GSR NOK K5NOK UXW Q\]GSK NO\#_ U RTNMOU a],sGS_ NOaJLNO\]GzMOGSa NOa UXWZNO\^àxaN D^à IMOGSaOGSRTNGS^`RDILK5IGJM m$ rV\]G MOGSa NOa GJMOGC_ U RaO^ aNGSRTNx x^ NO\DGSK5M ^`GJMxaN^`GSa,UXW K5IU |<KXRrly~^`R]GJN+ ^`_Ja *rV\]G _ U PAL^`RGSP/U~]G MOGXGSK GSK_ U aOGQMOG K5NO^ U R GJNo GJGSRrly:KXRK5IU |vIMOU~

(54) _ NO^Ù Ra KXR GJN GJGSR rHy<KXRQK5IU |IUqU aO^ JGSa Zw]UXMNO\]Gxa ] ,GS_ NOa ILK5MONO^ _J^ ILK5NO^`R] ^`RQNO\^à aNL XTNO\]GxIMOU~

(55) _ NO^ U R ,KXaVNO\]GzPQKX^ R>]GJNGJM PQ^ RKXRTN,UXW NO\]GzIUqU aO^ J G msRILK5IGJMlmOm G IMOGSaOGSRTNlNO\]GAM GSa NOaxUXWZNO\]G K5ILI ^`_JK5NO^ U RUXWZNO\]G P/UqG NUDNO\]G _ U R NMOU a ] ,GS_ NOa _ U P/ILK5M GS>NU J FpY[ a ] ,GS_ NOa Vu ]MVMOGSa NOaVaO\U NO\LK5NVNO\]GCU XGJMOIMOU~

(56) _ NO^Ù RUXWZn e F e ILK5M NO^`_ GSa ^`R ^`K5GJNGSa P/G ^ N a "N qI GVp^à +G ~I KX^`RGSC CGSR\LKXR_ GS/aGS_ MOGJNO^ U R UXW n e F e K5IU |KXRL rHy Fp^ MOGS_ N IMOU~

(57) _ NO^Ù R>UXWZn e F e K5IU | KXR[rly KXapR]UXNp^`R GSR_ GS> >^`K5GJNGSalI GJMpa G prV\]GAIMOU~

(58) _ NO^ U R M K5NGSa UXW n e F e rly KXRLK5I U |= GJMOGC_ U aOG MOG K5NGSKXa GJMOG NO\]G IU U aO^ JGSa UXW n e F e rHy KXR K5IU )| Tn e F e KXRLQn e F e _ U PQI U a ^ NO^ U R L^`/R]UXNL&^ % GJM^`R a ,sGS_ NOah x^ NO\QFpY"CKXRL _ U R NMOU aJ~KXR NO\]GCrHy NU K5IU | M K5NO^ U/UXWZR]GJ a ~RTNO\GSaO^àGSDILK5M NO^`_ GSa, ,KXa XGJM aO^`P ^ K5M ^`RDNO\]G No U XMOU ]ILa . 0B . r U aPQP 5K M ^àGpNO\^à ^ RTNMOU~

(59) _ NO^Ù R GzIM GSaGSRTNxNO\]GzPQK ,UXMxMOGSa NOa8 ( GH\KXGl]GXG UXIGSQK _ U PAL^`R]GSQP NO^~_ U P/I K5MONOP/GSR NOK P/U~]G NO\K5Nha ^`P NOKXR]GJUa CP/U~]G a NO\GILK5MONO^`_ GKXRrly NM KXRaW GJMQGJN GJGSR^% GJMOGSR NQ]GSRa ^ N"M KXR]XGSarV\]G>PQUq]G ^à Uq_JK ^ ]GSRTNO^ . K5 G KXR\KXaxR]U _ q_ GSa ( x\^ _ \K5M KXRTNGJGSapR]U R U a _J^ K5NO^`R aOU ]NO^ U Ra *$|M ^ G+ X NO\]G PQUq]G ^ aZ_ U RaNM _ NGSQUXW No UCP NO^~_ U P/I K5MONOP/GSR NOK a ~aNGSPQaZNO\LK5N ]GSaO_ M ^ G,NO\]G ILK5M NO^`_ G KXR rHy NM KXRaOI UXM NOa rV\]G W M KX_ NO^Ù RK NM KXRaOW GJMAM K5NGSazUXW,NO\]GQNo U"P/U~]G a K5MOG MOG K5NGS NUW UXM P%K _ U PAL^`RGS>P/U~]G rx\]GPQUq]G \KXa GJGSR K5II ^ GSCNUp UXNO\ \]GSK NO#\ C_ U R NMOU a ] ,sGS_ NOa KXR ^`K5GJNGSa P/G ^`N a"N qIG ( FpY" *pa ] ,GS_ NOa Crx\]G P KX^`RM GSa NOapK5MOG a ^ R&^ . _JKXR N >^`RL_ MOGSKXaGS[n e F e IMOU~

(60) _ NO^ U R[^`R FpY"[a ] ,GS_ NOa b U P/ILK5M K5 GQIMOU~

(61) _ NO^ U RUXWVn e F e KXRL W M KX_ NO^ U RK NM KXRaOW GJM M K5NGSa [rV\]G ^ R_ MOGSKXaGSn e F e IMOU~

(62) _ NO^ U R GSKXalNU*^`RL_ MOGSKXaGS[n e F e IUqU axKXRLNO\]GJM GJW UXMOG/K aOU NUKXR ^ R_ MOGSKXaGSK5LaOU ]NGDNM KXRaW GJM/W MOU P n e F e NU n e F e h l\^`_ \KX_J_ U R NOaQW UXMQKXR^`RL_ MOGSKXaGS n e F e I UqU ( G>L^àO_ aOaCNO\]G^`P/ILKX_ N UXWxM GSP/U 5K UXW K5G aCW MOU P NO\]GDNM KX_ GJMQKXRLILMOUXIU aG K"aNU~_ \KXaONO^`_ PQUq]G UXW NO\]G ^ W G>_ q_ G[UXW ^ IUXIM UXNGS^`RILK5MONO^`_ GSa rV\]G[K5NOK^ a R]UXN*a _J^ GSR N NU , LaNO^ W KaNU~_ \KXaNO^ _P/U~]G NO\LK5N ^à P/UXMOG_ U P/I +G NO\KXRNO\G_ U P/ILK5MONOPQGSRTNOK P/U~]G c U G XGJM l^ NO\P/UXMOG ]GJNOKX^ GSLK5NOK>UXW,NO\]G aN$M _ N ]M K _ \KXR]XGSaAUXW,NO\]G _ U P/IU aO^`NO^ U R"UXW NO\]G _ UXMOG*KXR NO\GAa ]M W KX_ GzUXWZNO\G ^ IUXIMOUXNGS^ R* ]M ^`R]/NO\GS^ MxP/GJNOK5U ^à P:P/UXMOGC_ U PQI +G >P/U~]G aV\KXaxNU G _ U RLaO^`]GJMOGS .

(63)

(64) .

(65) qi GS_ MOGJNO^Ù R / / / / 2 KXaOPQK z^`RGJNO^`_Ja / / / yHSG R]GJM K YUq]G UXW e ^ IUXIMOUXNGS^`RDYGJNOK5 U ^àOP / B V

(66) V |,KXaO^`_ h2 MOUXIGJMONO^ GSa / / / r M KX_ GJM"! NM KX_ GJG f ~ IGJM ^`P/GSR NOa / / / gxGS_ q _ ^ R] / / / i~KXP/I ^`R] / / / / YUq]G ^`R]/FHG K~ a / / / msP/I GSPQGSRTNO^`R G K~ a / / iqU ~ ^`R] upFpf / / / / rV^`PQGzFlGJIGSRGSRTNVr M KXRaW GJMxglK5NGSa / / w ^`R^ R] uHINO^`PQK 2 K5M KXP/GJNGJM a / / e GSKXaNla K5MOGSa / / / iqGSK5M _ \K XUXM ^ NO\PQa / / / iqUXW N ,K5MOG / / / / uHILNO^`PQ^àOK5NO^Ù R*^ Ri dld YmOm / / n K5M ^ KXR_ GCKXR GS^ \ NOa) / / ms]GSRTNO^. _JK5NO^ U R / / / / @ V Q ) B r M KX_ GJM"! NM KX_ GJG f ~ IGJM ^`P/GSR NOa / / / YGJNO\]UqLa / / / / r] M R]UX GJM1h2 MOUXNUq_ U / / / d RK ~ aO^à / / / FHGJNGJM PQ^ RK5NO^ U RUXWZfhRM ^`_ \LP/GSRTNOa,UXW e G _J^`R]G KXRy q_ GJM U rV\]G b KXP/I>f ~ IGJM ^`P/GSR N / / / f M MOUXM d RK ~ aO^à / / / = + . rV^`PQG ^`R]GJIGSR]GSR N,YU~]G a / / / Y NO^ b U PQILK5MONOP/GSR NxYUq]G UXW2 K5MONO^`_ GCr M KXRaW GJM y q _ GJMOU NU rly b U RX GJM a ^ U R>KXR c GJILK5NO^`_zrHyvYUq]G ^`R]' r U Fp^&% GJMOGSR NxYU~]G a / / = + . = 6

(67) . q^`^. . / / / . . . . J S . . . / / / / / / / / / / / / / / /. . . / / / / / / /. . . / / / /. . . . . . . . . X X .

(68) .

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(73) 5 5 . . . X X

(74) .

(75) . d b U PAL^`R]GSYU~]G / Vr ^`PQG FlGJIGSRGSRTNVYUqG a / / rV\GzkxU R}i~NGSKX }i~NOK5NG YUqG / Fp^àO_LaOaO^ U RDUXW NO\]GzrV^ P/GzFHGJI GSRL]GSRTN+hYU~]G msP/I GSPQGSRTNOK5NO^ U R>UXW klU R[iqNGSKX$}iqNOK5NG YU~]G a u ]NI ]NOaVw]MOU P:NO\]GCYUq]G a / / FHGSK ^`R] (=^ NO\r M KX_ GJM e U aOa / / = * V V YUq]G ^`R] NM KX_ GJM NM KX_ GJGA+G ~IGJM ^`P/GSR NOa / msP/I GSP/GSR NOK5NO^ U R / / . / / / / ^ Ri dld / / . / / / / / / /. . X X 5. . . . . / / / / .

(76) ^ . f ?; . msP/I GSP/GSR NOK5NO^ U R / / / . iqNGSKX$>i~NOK5NGCYU~]G / / . FpK5NOK / / / / . msP/ILKX_ NVUXW 2 UXI K5NO^ U R d XGJM K5XGSa / / . msP/I GSPQGSRTNOK5NO^ U R>UXW r M KX_ GJM e U aOa / / . 2 M GSaGSRTNOK5NO^Ù R>UXWZaU P/GCYU~]G GSK5NOK / / . i P PQK5M UXW 2 K5IGJMVm,KXRmOm / / . z ^ R]GJNO^`_ 2 K5M KXP/GJNGJM a / / / . FHGJNGJM PQ^ RKXRTNOaxUXW 2 MOU~

(77) _ NO^ U RDKXR b GSK5M KXR_ GAgxK5NGSa. FHGJNGJM PQ^ RKXRTNOaxUXW 2 UqU i~^ J GSa / / . FHGJNGJM PQ^ RKXRTNOaxUXW 2 KXaOP K/rly / / . Fp^àO_L aOaO^ U R / / / . rV\]G b KXP/I>f ~ IGJM ^`P/GSR N / / / . msP/I GSPQGSRTNOK5NO^ U R>UXW rV^ P/GzFHGJI GSRL]GSRTNVYU~]G / C B B ) B r M KX_ GJM a / / / / 5 5 q q p ~ _ GJMOU / / uHNO\GJMxr M KX_ GJM aVW UXMxrly ~ ^`R]GJNO^ _Ja / / f ~ NGSR^ R]/NO\]GzYUq]G / / / f q NGSRL^`R] NO\]GCFHGSRaO^`N" gxKXR]XG / / d ^`R YUXMOG e KX GJM a / / iqGJI K5M K5NO^ U RUXW 2 K5NO\T ,K~ a / / iqNU~_ \KXaONO^`_zYUq]G ^`R]/KXR'2 K5MONO^`_ GCFHGSRaO^ N / Fp^àO_ a aO^ U RDU RNO\]GArV^`P/G FHGJIGSR]GSR NxYU~]G / d d I U |<KXRL>rly N] M R]U X GJMlIMOUXNU~_ U / / d msaU K5NO^ U RUXW ^Ì UXILMOUXNGS^`Ra / / / d |,^ U~_ \]GSPQ^ _JK KXRK ~ aGSa / / / d FHGJNGJM PQ^`RLK5NO^ U R>UXW G _J^`RGHGSRM ^`_ \LP/GSRTNV^ RK5I U | / d FHGJNGJM PQ^`RLK5NO^ U R>UXW ~ _ GJMOU GSR]M ^ _ \P/GSR NV^`Rrly / . YmOm .

(78) .

(79) . . . / / / / / / / / / / / / / /. . . . / / / / / / / / /. . . . / / / / /. . . .

(80)

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(93) . B P . P.

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(100) H . . msR>NO\^àx_ \K5INGJMp GC ^!XG KQM ^ GJW ^ RTNMOU~

(101) _ NO^Ù RNU ^Ì UXILMOUXNGS^`Ra KXR ^ IUXIMOUXNGS^ R q^`RGJNO^`_Ja d P/UXMOG ]GJNOKX^ GS]GSaO_ M ^ ILNO^ U R_JKXR>GpW ULR^`RDNG+~NxU U

(102) ~a KXa e ^Ì UXILMOUXNGS^`RaZK5MOGxNO\]GxNM KXRLaIUXMONGJM aZUXWNM ^` q_ GJM ^`]G ( rly *ZKXR _ \]U GSaNGJMOU GSaNGJM ( b f *Z^`R/NO\]Gl UqUq a ~aNGS' P ,rV\]G D_JK5MOM ^ I ^àW M U P NO\]GC^`R NGSaNO^`RGCKXRNO\]G ^!XGJMVNU*aXG GJNOK PaO_ GSaJLKX^ IU aG NO^ aOa]G KXRK aULKX_ NU[NO\]G !^ XGJM d a rly:KXRL b f P/U GS_ GSaCK5M G*R]U R I U K5MzNO\]G K5MOGD\#q]M UXIL\]UXL^`_ rV\]G ^ IUXIM UXNGS^`RaxK5M G K P/U aN aIL\]GJM ^`_JK I K5MONO^`_ GSaH x^ NO\[K_ UXMOG UXWrHy KXR b *f i]M MOUR^ R]/NO\]G _ UXMOGANO\]GJMOGC^àxKQP/U R]U K XGJMlUXW IL\U aIL\]U ^ÌL^` ( 2 e * KXR>W MOGJGC_ \]U GSaNGJMOU ( w b *$ rV\]GzW K5NN">KX_J^`NOKX^ UXWZNO\]G 2 e ^àVR]U R IU K5MlKXR>IU ^`R NOax^`R ,K5M aJLPQGJGJNO^`R]QNO\]G R]U R IU K5Mx_ UXM G ^ÌL^à rV\]GzIL\U aIL\]UXM XMOU ]I[^àlI U K5MxKXRI U ^ RTNOaxU ]N ,K5M alW M U P:NO\]G aO\]G PQK q^ R] NO\]GAILK5MONO^`_ GCPQ&^ G x^`NO\> ,K5NGJM rV\]Gzw b aNOK5L^ ^àGSaNO\]GCa \]G ~P L_ \ !^ XGpU R]G K XGJMxUXWZK/P/GSPAM KXR] G Fp&^ %GJMOGSRTNZILMOUXNGS^`RaZK5MOGlK5NNOKX_ \]GS NUzNO\]GVa MOW KX_ G ZrV\GSaG IMOUXNGS^`RLaJ _JK GS/K5IU ^ IUXIM UXNGS^`RaJ5^`R NGJM KX_ N x^ NO\zGSR qPQGSa ^`RzNO\]GhI KXaOPQKVKXRCNO\]GK5M NGJM ^`K ,K a KXRzMOGJ K5NGSa NO\GP/GJNOK5U ^à P<UXW]NO\]GhI K5MONO^`_ G rV\]GJM Gx+G ]^àNhaG XGJM K 5K5M ^`KXR NOaUXW ^ IUXIMOUXNGS^`RLaZK aO\LK5M ^`R]zNO\GlaNM L_ N ]MOGlGSaO_ M ^ GSQK5U XGH ]Nh x^ NO\ &^ %GJMOGSR N ~^`R]GJNO^`_ GS\K q^ÙXMhKXR L&^ % GJM GSRTN NOKXa qa rx\]GJMOGxK5MOGlNO\]MOGJGHPQKX^`RQ_JK5NGJXUXM ^`GSaUXW ^ IUXIMOUXNGS^`Ra rV\]G *K5MOGCaN$M _ N ]M K &^ %GJMOGSR N,KXaVNO\]G *_JK5M M *L&^ % GJM GSRTN K5IU ^ IUXIMOUXNGS^ RaJq ]N,NO\]G DK aUQ&^ %GJM ^`R NO\]GS^ MVGSRaO^ N

(103) 0; +

(104) . rV\]GK5IU | JX_JK5MOM ~^`R] ^ IUXIMOUXNGS^`Ra*K _JK5M M +G ]KX_ N U RG P/U GS_ G/UXW,K5IU ^Ì UXILMOUXNGS^`R[| JX ( K5IU | JXUXM ,aN K5IU | *$ rV\L^àpP/U GS_ GQ_JKXRLR]UXN GHMOGSP/U XGSUXM MOGJI KX_ GSD ]N^ a LR^ ]GxW UXM,GSKX_ \ILK5M NO^`_ G rV\]GpK5IU | _JK5M M q^ R] ^ IUXIMOUXNGS^`Ra K5M Gl!^ ~^`]GS ^`R NUC^ % GJMOGSR N XMOU ILaJT]GJIGSRL^`R]pU RQNO\]GS^`Mh]GSRaO^`"N ZrV\]G K5MOXGSaNJ KXRL P/U aNrly M ^`_ \ZI K5MONO^`_ GSa \K XGNO\G U GSaON GSRaO^ N KXRK5MOGD_JK GSnZGJM e U :FHGSRaO^ N e ^ IUXIMOUXNGS^`Ra ( n e F e * ^`R NGJM P/GSL^`K5NGhaO^ JGSzILK5MONO^`_ GSa K5MOG_JK GSzmsRTNGJM PQGS^`K5NGhFHGSRaO^`"N e ^Ì UXILMOUXNGS^`Ra ( msF e * KXRLNO\]G ILK5MONO^ _ GSax l^ NO\>NO\]G MOG K5NO^ XG \^ \]GSaNH]GSRaO^`"N >K5MOG NO\]G e U vFHGSRaO^`"N e ^ IUXIMOUXNGS^`Ra ( e F e *$]rV\]GHn e F e ~m}F e KXR e F e K5MOGpNO\]GpaOKXP/GpILK5M NO^`_ GSa ]NK5N ^ % GJMOGSR N,aNOK5XGSa ^`R NO\]GS^ M PQGJNOK5 U ^àO'P CwUXMC^`RaNOKXRL_ GX x\]GSR"KDn e F e U aG/rly ^ NpW UXM PQapKDmsF e rV\]GSaG ILK5MONO^ _ GSa K5MOG a qR NO\]GSaO^àOGS ^`R KXR aOGS_ MOGJNGSDW M U P NO\]G !^ XGJMKXR NO\GS^ MPQKX^ R NOKXa ^à NU NM KXRaIUXMON ^ IL^ aZKXR _ \]U GSaNGJM U NU a XG GJNOK P aO_ GSaVKXRLKX^ IU aG NO^àOa ] G ; 2 K5MONO^`_ GSaCaO^`PQ^ K5MHNUNO\]G/n e F e K5MOG W UXM PQGS ^`R"NO\]G ^`R NGSaNO^`R G QrV\]GSaG/ILK5M NO^`_ GSa K5M G _JK GS_ \ U PQ^`_ M U RalKXRL[^ RaNGSKXUXWhK5IU | JX~NO\GSaGAI K5MONO^`_ GSaHK5MOG G ^ÌIGS> x^ NO\KXR K5IU ^Ì UXILMOUXNGS^`RC_JK GS/K5IU ^ IUXIMOUXNGS^`RA| ( K5I U | *$hrx\]G K5I U | pP/U GS_ G ^à ^`]GSR NO^`_JK .

(105) .

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(140)

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(145)

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(151)

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(156)

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